264 results
Knowledge on the magnitude of the decline and the pathophysiological mechanism can eventually help us topostulate an algorithm for well-balanced decision making in treatment strategies in the elderly CKD patients.This knowledge will be firmly…
To compare Bone Material Strength of the tibia at the side of a fracture or arhtrodesis with that of the opposite tibia in patients who had been immobilized for at least 6 weeks after a recently sustained fracture of the ankle of calcaneus or after…
To study the effects of transient severe endogenous stress hormone exposure on the structure and functioning of brains circuitry regulating emotion, and the association with cognition and psychopathological symptoms.
The main objective of this proposal is to request permission for recruitment and participation of individuals between ages 8 and 30 in an fMRI session and several behavioral testing sessions. These studies are aimed at relating brain development to…
Performing this experiment will give proper insights in nutrient sensing after nutrient intake in normal cells. The feasibility of measuring these nutrient sensors and the potential of ensuring sufficient quantity of lymphocytes will be explored.…
Is there a better way to detect REM sleep atonia than with the current visual analysis of submental muscle EMG? To which degree do muscles become atonic during REM sleep? Which muscle exhibit the largest decrease? How can this decrease best be…
Primary:To investigate the effect of VLCD (very low calorie diet) in obese patients with type 2 DM and cardiovascular complications on cardiac function, pulse wave velocity and myocardial triglyceride contentSecondary:To investigate the effect of…
The aim of the present study is to investigate cerebral vasoreactivity in response to lower body negative pressure in young and elderly healthy men, as a measure of cerebral autoregulatory responsiveness.
Primary objectivesTo evaluate the prevalence, and incidence in yearly intervals, of pituitary insufficiency after cranial irradiation or total body irradiation at long-term follow-up. Secondary objectiveTo evaluate the impact of cranial irradiation…
The aim of the represent proposal is twofold, 1. [PHASE 1] the establishment of a human tissue biobank including muscle and blood, and additionally from a subset subset of subjects fat and skin biopsies will be taken. Samples will be distributed…
1. Assessment of sensitivity of several outcome measures in muscle force and function in Duchenne muscular dystrophy2. Assessment of reproducability of different outcome measures3. Assessment of clinical relevance of measured change over time in…
This study has been transitioned to CTIS with ID 2024-514841-12-00 check the CTIS register for the current data. Primary Objective:To compare invasive disease-free survival (iDFS) for the combination of at least 5 years endocrine therapy and 2-year…
This study has been transitioned to CTIS with ID 2023-504694-20-00 check the CTIS register for the current data. - The primary objective of the Stratum 1A cohort is to establish the maximum tolerated dose of single agent InO when administered in…
This study has been transitioned to CTIS with ID 2022-502526-41-00 check the CTIS register for the current data. Objective- To evaluate anti-tumor activity of pembrolizumab (MK-3475) by evaluating the absence of high risk NMIBC or progressive…
This study has been transitioned to CTIS with ID 2023-509305-68-00 check the CTIS register for the current data. To evaluate the long-term safety and tolerability of ralinepag (ADP811) in subjects who participated in a preceding Phase 2 or Phase 3…
This study has been transitioned to CTIS with ID 2024-514233-37-00 check the CTIS register for the current data. To evaluate the feasibility and prove the concept of sentinel node biopsy in patients with carcinoma of the parotid gland and scheduled…
This study has been transitioned to CTIS with ID 2023-507146-91-00 check the CTIS register for the current data. Primary Objective:• To evaluate the safety and tolerability of viltolarsen administered intravenously (IV) at weekly doses of 80 mg/kg…
To explore feasibility and efficacy of endoscopic unilateral drainage of patients with presumed perihilar cholangiocarcinoma eligible for major liver resection using a novel fully covered metal stent with a retrieval string.
This study has been transitioned to CTIS with ID 2023-509318-13-00 check the CTIS register for the current data. This is an open-label, multi-center, roll-over study designed to provide continued access to subjects who have previously participated…