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Biobanking of testicular biopsies from azoospermic men undergoing testicular sperm extraction (TESE)

Biobanking of a testis biopsy from men with azoospermia who undergo a TESE procedure to allow investigation for understanding the etiology of male infertility, research about normal and aberrant male gamete formation in its natural environment of…

Optimization of the Conditioned Pain Modulation Protocol using the Q-sense

In the current study, we will 1) evaluate the usefulness and reliability of this new device, and 2) evaluate whether the anatomic site used will impact the measured CPM effect.

The neural correlates of age-related variability in grammar learning:
an neuroimaging study of maturation effects on grammar learning skills in children and adolescents.

To investigate whether age-related differences in grammar acquisition primarily reflect maturational changes in neural plasticity and pathways that support learning and consolidating of new linguistic knowledge and skills.

Liking of e-liquid flavors: correlation between smelling and vaping

Research on e-liquid flavors could be performed through smelling or tasting (*vaping*) experiments. The main objective of the Smell-e study is to determine if there is a correlation between liking of e-liquid flavors through smelling and liking of e…

Exploratory Biomarker Study of Fatty Acid profiles in Healthy Volunteers and patients with Parkinson's Disease

- To investigate the baseline profile and inter- and intra-subject within-day and between-day variability of the fatty-acid profiles including fatty-acid desaturation index (FA-DI) and PUFAs in the plasma of patients with Parkinson*s disease and…

A Phase 1, Open-label, Single-dose, Randomized, Crossover Study to Assess the Local Tolerability of the Tildrakizumab 200 mg Dose when Delivered as Single Subcutaneous Injection via the 200 mg/2 mL Pre-filled Syringe

The purpose of this study is to investigate how well a new dosage form of tildrakizumab is tolerated when it is administered to healthy volunteers. Tildrakizumab (also known as Ilumetri) is no new compound; it is already available on the market as a…

A Non-Interventional Mechanistic Study to Characterize Biomarkers for Mitochondrial Dysfunction and Inflammation in Subjects with Mitochondrial Disorder and Cardiomyopathy, and Healthy Volunteers

To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.

The cerebellum in anger and behavioural inhibition: An fMRI study

To assess the spatial topographical representation of anger and behavioural inhibition in the cerebellum.

A methodology study quantifying mast cell density in healthy volunteers

To quantify and assess intra- and inter-subject variability in mast cell density among healthy male and female volunteers. Serum tryptase values will also be quantified.

A Single-Center, Prospective Study in Healthy Volunteers for Validation of the O3 Regional Somatic Tissue Oxygenation Monitor

The objective of this study is to assess the performance of the Masimo O3 regional oximeter on somatic tissue oxygenation, under controlled hypoxia. Somatic rSO2 values will be compared with combined arterial and venous blood gas measurements from…

THE IMMUNE SYSTEM IN FOXP1 SYNDROME

Primary Objective: We aim to provide a clear phenotype of the immune system in patients with FOXP1 syndrome. Secondary Objectives:We aim to correlate the immunophenotype of patients with FOXP1 syndrome with frequency and type of infections reported…

A multi-center, real-world exploratory cohort study to evaluate cough frequency, severity, and impact on quality of life in patients with non-idiopathic pulmonary fibrosis interstitial lung disease

The overall aim of this study is to assess the frequency, patient-reported severity and impact of cough, and the distribution of coughing fits during the daytime and nighttime, in a population of patients with non-IPF ILDs.Primary objective: The…

A randomized, multi-center, open-label, cross-over study comparing critical errors, overall errors, training/teaching time, and preference attributes of the ELLIPTA dry powder inhaler versus the BREEZHALER dry powder inhalers, in adult participants with mild to moderate asthma.

Primary objective:To compare the proportion of participants who make at least one critical error after reading the section on inhaler use in the patient information leaflets (PILs) for ELLIPTA and BREEZHALER inhalersSecondary Objectives:To compare…

A dermal inflammatory challenge study to evaluate complement activation in healthy volunteers

Primary objectives• To evaluate complement activation after topical imiquimod challenge• To evaluate complement activation after local UV-B challenge

Protocol for gathering data for the pediatric control groups of various CHDR trial@home studies with wearable technology and smart-phone applications.

- To determine the tolerability, feasibility and quality of the employed methods of data collection in different age groups. - To investigate inter-subject variability and normal-values regarding step count, heart rate, sleep duration, blood…

Subtyping of Insomnia

The primary objective of this study is to identify clinically relevant subtypes of insomnia using mainly physiological parameters. Mainly macro and microstructural parameters of the EEG will be used, as well as parameters from ECG and finger PPG.…

Screening of the immune repertoire of healthy volunteers for broadly reactive fusion-inhibiting antibodies directed against coronavirus S protein, including SARS-CoV-2

To screen the immune repertoire of healthy volunteers for broadly reactive fusion-inhibiting antibodies directed against coronavirus S protein, including SARS-CoV-2 f and (if found) to isolate/clone and further characterize such antibodies with the…

Recovery after critical illness

Evaluation of the change in health-related quality of life (HRQoL) and physical and mental health of critical illness survivors.

HIV-1 Envelope Sequence Diversity Within the Latent Reservoir in HIV-1 Infected Individuals Initiated on Antiretroviral Therapy (ART) During Acute and Chronic Infection.

To determine the frequency of R5-tropic N332+ viral isolates present within the latent reservoir while on suppressive ART.

The impact of passive heat treatment on skeletal muscle perfusion capacity and post-prandial muscle protein synthesis rates in healthy older adults.

To compare the post-prandial muscle protein synthetic response following ingestion of a whole-food meal (560kCal; 30g protein total) before and after a 8-week passive heat treatment intervention in healthy older men and women.