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A phase-I open label, balanced, randomized, crossover, two-groups, two-treatments, two-period, pilot study in healthy male subjects to determine the feasibility of a multiple dose dispenser for testosterone intranasal gel as measured by pharmacokinetics

The purpose of this study is to demonstrate the effectiveness of the multiple dose dispenser in comparison to the syringe as measured by a testsoterone pharmacokinetic profile

Measurement of testosterone in muscle tissue using microdialysis; a pilotstudy

To study how testosterone levels in muscle tissue compare to plasma levels in males.

Correlation between salivary testosterone and free testosterone

To study the correlation between salivary T and (measured and calculated) serum free T.

A phase I open-label, balanced, randomized, crossover, three-groups, three-treatments, three-period, pharmacokinetic study of intranasal testosterone gel administration to healthy, adult, male subjects

The purpose of the study is to determine the PK profile of three different intranasal testosterone formulations.

The Cycle disturbances, OLigomenorrhea and Amenorrhea (COLA) Study

This research proposal has multiple aims for research in women with WHO I, II or III status, including extended care and general health assessment, diagnosis/etiology, assessment of best approach/treatment, cardiovascular risk assessment, and…

Women*s Hormonal Intervention Study in early Postmenopause of Estradiol-progesterone Replacement therapy - effects on quality of life

To evaluate health related QoL under an oral cyclic treatment with physiological steroid hormones: Duogestan®.

individueel setpoint Hypothalamus Hypofyse Gonade as bij de man; een pilotstudy

To study whether there is an individual setpoint for the hypothalamus-pituitary-gonad axis in men

The role of inactive follicle stimulating hormone in ovarian dysfunction in galactosemia.

1) To assess whether galactosemia women with ovarian failure are able to produce estradiol after exogenous (normally bioactive) FSH and LH gift 2) To characterize FSH glycan structures

FSH receptor polymorphisms and treatment of poor responders

The hypothesis is that women who have the Ser680Ser (SS) variant of the FSH receptor genotype, in comparison with women with the Ser680Asn (NS) or Asn680Asn (NN) variant, are less sensitive to FSH and because of that need higher dosages of FSH when…

plasma testosterone levels in hypogonadal individuals treated with AndroGel, impact of showering shortly after application

to investigate whether showering shortly after Androgel application adversly affects plasma testosterone levels.

Biomarkers in Kennedy Disease
The identification of biomarkers as clinical endpoints in drug efficacy trials in Kennedy disease; an international academic multicenter study in Utrecht and Leuven

The main objective of this prospective population based cohort study of patients with KD in the Netherlands and Flemish part of Belgium is to perform multiple tests (i.e. clinical and blood) and genomic profiling to discover possible biomarkers for…

LH and FSH relaese by the pituitary, de inhibitive effect of estradiol in male to female transsexuals

to study the effect of estradiolapplication on gonadotropin relaese in young and older men in the abscense of circulating testosterone.

Preservation of ovarian cortex tissue in girls with Turner syndrome:
A multicenter exploratory intervention study

To investigate the occurrence of live birth in women with TS after ovarian tissue cryopreservation in childhood followed by auto transplantation in adulthood.

Turner And Klinefelter Treatment Target study

To explore the relationship between hormone levels and HRQoL in patients with TS and KS.

Long-term follow up of overweight and obese women with PCOS who participated in a randomized controlled three-component lifestyle study

The aim is to evaluate long-term (+/- five years post-intervention) follow-up results of a previously completed study that investigated the effect of a three-component (diet, exercise, cognitive behavioural therapy (CBT)) lifestyle intervention with…

TETRA-pilot: Testosterone in transgender women after vaginoplasty: a dose-finding and feasibility pilot study

The primary objectives are to establish dose-response relationship for 2% transdermal testosterone (Tostran®) gel to achieve total testosterone serum concentrations between 1.5-2.5 nmol/l in transgender women after vaginoplasty and to assess side…

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek - Reproductive potential in male survivors of childhood cancer

1. To assess the prevalence of severe male subfertility in adult male survivors of childhood cancer in relation to type and intensity of treatment and age at time of treatment. 2. To assess the diagnostic value of inhibin B and AMH for the…

Turner syndrome minipuberty study

The hormonal range of LH, FSH, AMH, inhibin B, testosterone and estradiol in girls with TS during the minipuberty and the relation of the hormone serum levels with the karyotype.

Semen characteristics and testosterone levels in the general population

1. Evaluation of the variation of semen characteristics in the general population2. Evaluation of the variance of testosterone levels in the general population