36 results
Primary Objective: 1. To investigate the anatomical location of a TAVI-induced LBBB. Secondary Objectives: 1. To investigate during which phase of the TAVI-procedure the conduction disorder develops.2. To investigate predictors for the occurrence of…
Primary objective: to identify intra-individual changes of clinical and biochemical markers of AT characteristics before, and one year after bariatric surgery by:* Determining circulating AT derived biomarkers * Determining local AT biomarkers in…
To investigate the real incidence of POAF a Reveal device is implanted. Afterwards a risk stratification of POAF is made.Using modern mapping equipment and techniques, it is now possible to investigate the substrate for development of atrial…
The main objective is to find markers for arrhythmia vulnerability in patients with end stage heart failure.
Primary objective:To assess the two-year prevalence and incidence of clinical relevant arrhythmias in drug-resistant epilepsy.Secondary objective:To assess whether the recorded cardiac arrhythmias are related to epileptic seizures (subjectively from…
To establish evidence on the effectiveness of long term rhythm observation using an implantable loop recorder for detecting atrial fibrillation in patients with cryptogenic stroke.
To phenotype and genotype the population of patients with IVF in our cohort, and to find alternative diagnoses as a cause of the event of VF.
The aim of this project is to elucidate how corticosteroids protect cardiac surgical patients from PNAF. We will therefore examine the modulating effect of prophylactic high-dose corticosteroid administration on perioperative risk factors for PNAF.…
The objective of this study is to investigate cardiac sympathetic ativity in subjects with 22q11DS and the effect of catecholamine depletion.
The objective of this study is to determine the frequency of previously undiagnosed SCN5A mutations leading to sudden death in temporal association with vaccination in The Netherlands.
1) To electrophysiologially characterise a selected, large cohort of patients prone to malignant ventricular arrhythmias (ICD recipients)2) To exactly quantitate outcome by total mortality as well as malignant arrhythmia risk through number of…
This study that documents the changes in heart rate, muscle sympathetic nerve activity, stroke volume and systemic vascular resistance in response to supine and head up tilted carotid sinus massage in elderly subjects.
In the present study we aim to identify the genetic modifiers in this family which underlie differences in severity and type of phenotype by means of linkage analysis.
The primary objective is to establish whether patients are at increased risk for VT/VF during inflammation. The secondary objective is to establish whether increased risk during inflammation is mediated by hyperthermia and inflammatory cytokines.…
To determine the impact of catheter ablation on the left atrium by visualizing scar tissue in the left atrium, using delayed enhancement MRI, and to correlate this to possible changes in left atrial size and function following catheter ablation.
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
With iPS-CM we want to elucidate the effect of mutations on cellular and molecular level. With this knowledge it will be possible to understand the mechanism underlying heterogeneity in various arrhythmia syndromes, which will open the door for…
The main objective of this study is to investigate the relation between Cx40 polymorphism and protein expression in the general population and patients without a history of AF.
The goal of the proposed study is to study the relationship between chronic atrial dilatation and the electrophysiological properties of the atria in subjects with chronic AF. Furthermore, we would like to study the effect of acute atrial dilatation…
The primary objective of this study is to identify atrial tissue miRNAs that are associated with the incidence of AF and histological alterations in a population of patients without documented AF. Secondarily, this study will validate AF associated…