258 results
In this study we will study the incidence of QTc-interval prolongation when combinations of 2 or more QTc-prolonging drugs are prescribed. Also we will investigate if QTc-prolongation is more frequent in patients with higher drug plasma…
Primarily, this study aims to investigate (i) the feasibility and safety of a novel temporary epicardial pacing wire placement using two unipolar pacing electrodes embedded in a gelatin sponge and (ii) the stability of electrical performance of the…
The objective of the pilotstudy is feasibility and safety.
The aim of this study is to identify CHF patients who are most likely to benefit from ICD therapy by the use of clinical patient characteristics related to CHF combined with a measure of myocardial sympathetic integrity/activity. This will enable to…
The purpose of this Clinical Investigation Plan is to collect data on the safety and performance of the WiCS-LV system. It is designed to satisfy requirements for clinical data and post market clinical follow-up for the Active Implantable Medical…
To identify that fysical complaints fitting with atrial fibrillation, hyperthyroïdie, left atrial enlargment at ECG, left ventrikel hypertrophy at ECG, premature atrial complex (with heartbeat > 70 bpm) at ECG and cerebral ischemic attacks in…
To collect information of 1000 patients per coumarin (acenocoumarol and phenprocoumon) to investigate the impact of height and weight on the dose needed. The database will also contain other information of the patient, like age, gender and genotypes…
The primary objective is to establish whether patients are at increased risk for VT/VF during inflammation. The secondary objective is to establish whether increased risk during inflammation is mediated by hyperthermia and inflammatory cytokines.…
To determine the impact of catheter ablation on the left atrium by visualizing scar tissue in the left atrium, using delayed enhancement MRI, and to correlate this to possible changes in left atrial size and function following catheter ablation.
Primary efficacy objective: to test that patients with permanent or persistent AF and concomitant diseases requiring open heart surgery will be free of AF when treated with the Cardioblate Surgical Ablation System using a modified Maze III procedure…
The purpose of this study is to evaluate and document appropriate clinical performance of the new RELIANCE Quadripolar (4-SITE) defibrillation lead and the 4-SITE Header / Lead interface when connected to the TELIGEN 100 HE 4-SITE (VR or DR)…
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
To find the predictors of ventricular arrhythmias in patients receiving an ICD
The purpose of this study is to do research what the effect of the BMI and fat percentage is on the speed of cooling.
Primary objective 1To quantify the 24-hour AF burden accuracy in patients with more than 1% AF burden. Primary objective 2To quantify the detection accuracy of non-arrhythmia in patients with 1% or less AF burden.
With iPS-CM we want to elucidate the effect of mutations on cellular and molecular level. With this knowledge it will be possible to understand the mechanism underlying heterogeneity in various arrhythmia syndromes, which will open the door for…
To assess whether pacing from the right ventricular outflow tract, the right ventricular apex or combined pacing shows difference in right and left ventricular ejection fraction and asynchrony.
The main objective of this study is to investigate the relation between Cx40 polymorphism and protein expression in the general population and patients without a history of AF.
To study the underlying pathophysiological substrate of atrial fibrillation in the individual patient by intraoperative measurements and histological analysis of atrial tissue. With this method we may identify patients that do not favor from…
The purpose of this study is to evaluate and document that the clinical performance of the TELIGEN 100 HE and COGNIS 100 HE systems and associated application software is within design specifications. It will also document the appropriate clinical…