353 results
Validation of the DBS sampling method of cyclosporin in TDM practice
To assess whether TW and PW show differences in number, phenotype or function of regulatory T-cells in peripheral blood samples. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; PREDART0807…
We here propose a pilot immuno-PET study in active relapsing MS patients to investigate safety and sensitivity of 89Zr-rituximab in detecting CD20 positive (active) MS lesions and to assess inter-patient variability in 89Zr-rituximab biodistribition…
The objectives of this study are:* To determine the percentage of patients with recent-onset RA and UA who achieve and maintain clinical remission on treatment with a combination of methotrexate 25 mg/week and extended prednisone pulse (tapered high…
To evaluate the reproducibility of DCE-MRI measurement of the joints analyzed by color coded shape mapping, and by compartmental model analysis.
Primary: To assess the effects of visilizumab on the safety of subsequent salvage therapies in subjects who experienced disease progression in a previous visilizumab study and subsequently received salvage therapy (see Definitions).Subjects will be…
The objective of the study is to see whether oral administration of probiotics can modulate certain immunological markers which are associated with accelarated atherosclerosis in patients with ANCA associated vasculitis.
Construction of a biobank with peripheral blood and skin biopsies from patients with SSc, to evaluate (new) antigens and/or (new) antibodies and/or RNA expression profiles and to correlate these findings with clinical parameters (i.e. disease…
We hypothesized that one of the key mechanisms explaining the differences in effect between adalumimab and etanercept on psoriatic skin is that adalumimab, by being a monoclonal antibody like infliximab, is a better inducer of apoptosis resulting in…
To assess the effect of adalimumab and rituximab on the safety and efficacy of vaccination with T cell-dependent and T cell-independent primary and recall antigens.
The ulitmate goal of the current study will be the presentation of a specific minimum core set of outcome measures to be used in future clinical and follow-up studies in patients with autoimmune mediated polyneuropathies.
The primary objective of this study will be overall response to treatment with Estetrol in patients with primary Sjogren*s syndrome.
To determine the efficacy and safety of tocilizumab in the daily clinical practice situation for at least 36 months in comparison to the reported efficacy and safety in clinical trials.There will be a particular focus of the effect of tocilizumab on…
Test efficacy of compounds D+E in humanized mouse model of psoriasis.
Is topical application of compound Z effective in reducing the development of psoriasis, induced in this humanized mouse model?
The identification of axial SpA in the primary-care setting and the introduction of questionnaires that could optimize the pattern of referral to secondary care is one of the most important objectives of the CAFASPA study.
Compare the prevalence of disease characteristics in activity as well as damage in patients with Behcets disease in the Netherlands, United States and Turkey.
To evaluate the response to etanercept treatment in TNF-alpha blockade naïve patients and patients who failed prior other anti-TNF-alpha treatment and to understand the mechanisms underlying the clinical response to TNF-alpha blockade
Primary objective:to study changes in synovial inflammation and cytokine expression in serial biopsy samples following the administration of adalimumab in patients with active rheumatoid arthritis.Secondary objectives: (i) assess clinical response…
Primary Objective: The primary objective of the study is to assess long-term safety of AMG 108 (125 mg, 250 mg) SC in subjects with RA previously enrolled in study 20050168.Secondary Objective(s): The secondary objectives of the study are:* To…