353 results
This study aims to assess the illness perceptions and HRQoL in patients with lupus nephritis. Is HRQol higher in patients that received the Euro-Lupus schema compared to patients treated according to the NIH-protocol? A second aim is to screen the…
This study aims to show that the IFX or AZA are equally effective with the latter being more efficient as maintenance therapy in CD after remission induction with IFX/AZA for at least 6 months as defined by the proportion of patients not needing…
Answering the following research questions:1. Have circulating inflammatory factors a central role in the pathogenesis of regional and general osteoporosis in different inflammatory diseases?2. Which inflammatory factors have a key role in this…
To evaluate the safety and tolerability of FFP104 in PBC subjects following repeat doses of FFP104
The goal of this stdy is to investigate both antibody responses in an invitro culture system which prevents clearance of antibodies and provides the oppertunity to study the antibodies in an antigen-free environment. This should lead to more insight…
A proof-of-concept study in refractory SLE patients to assess the immunological consequences of a combination treatment with rituximab (anti-CD20) and belimumab (anti-BAFF) to achieve long-term B-cell depletion. The immunological and clinical…
The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…
Primary Objective: To identify new immunological markers for therapeutic response to anti-TNF therapy in chronic granulomatous diseases.
To assess the efect of IL-17 blockade on:- the global synovial histology and inflammatory infiltration- the number and type of IL-17 producing cells in SpA synovitis- the productuion of inflammatory mediators (including other IL-17 related cytokines…
The key objective of this proposal is to develop a prediction tool, which will enable clinicians to detect an increased risk of developing chronic pain in JIA at an early stage of the disease. This tools consists of an assay for GRK2 expression.…
Primary Objective* To estimate the proportion of subjects who flare within 40 weeks followingwithdrawal of ETN in subjects who have achieved ASDAS CRP less than1.3 (inactive disease).Secondary Objectives* To estimate time to flare after withdrawal…
The purpose of this study is to obtain blood samples from up to 14 subjects who previously received namilumab in the previous study M1-1188-002-EM (PRIORA, [NCT01317797]) to correlate genetic markers with clinical outcomes.
Our aims are to identify the clusters of impairments in cognition, behavior, quality of life, and fatigue in children after anti-NMDAR encephalitis, to identify risk factors affecting functional outcome and to assess the progression or remission…
• To determine the immunogenicity prediction in PBMCs of patients treated with Infliximab and Adalimumab using the MAPPs assay.• To investigate whether the peptides presented upon in vitro loading of Dendritic Cells are also presented in vivo after…
to investigate pathogenic mechanisms in synovial tissue driving inflammatory rheumatic diseases in relationship to phenotype, disease duration and stage and in relation to systemic immunity, to identify new diagnostic and therapeutic targets.
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs), delivered in a gel, on psoriasis skin biopsy gene expression in vitro.
The main objective of this study is to investigate the effectiveness of the humeral and cellular immune response after tetanus revaccination in patients with AChR MG, MuSK MG, or LEMS. The secondary objective is to determine if revaccination induces…
Natalizumab (Tysabri®) for the treatment of anti-Hu associated paraneoplastic neurological syndromes
The primary objective of the study is the functional improvement with one point or more on the modified Rankin scale after the 12th week of natalizumab (compared to baseline).
The present study will evaluate if supplementation of the diet with riboflavin in Crohn*s disease patients will result in a similar increase in the number of F. prausnitzii as seen in the healthy volunteers. Potentially an even larger effect can…
To determine the prognostic value of transient elastography (Fibroscan) in PSC patients.