37 results
First, to explore relationships between immunological factors (cytokines and chemokines), psychological stress, and pain, controlled for infection. Second, to explore relationships between immunological factors (MBL), bacterial colonisation and…
The primary objective of the study is to determine sensitivity, specificity, positive and negative predictive value of the enzyme analyses (myeloperoxidase, human neutrophil elastase and lysozyme) with wound biopsies as the gold standard.…
The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
The purpose of this study is to obtain an impression of the general image quality and clinical value of leucocyte PET/CT in visualizing infectious foci in the body.
To evaluate molecular assays for the detection and quantification of bacterial DNA in blood of patients with bacteraemia. Objectives are to determine the diagnostic performance of five molecular assays for the detection of bacteraemia in patients…
1. To identify and specify bacteria by using RT-PCR on blood and cerebrospinal fluid (CSF) in preterm infants, having nosocomial sepsis and meningitis.2. To compare RT-PCR (see aim 1) with the gold standard bacterial culture in preterm infants,…
The primary objective is: The minimum time in days after treatment for Ng to perform a TOC using NAAT and DNA PCR. Secondary objectives are: Time to clearance per infected location. Host and pathogen related factors associated with time to clearance…
Primary we aim to investigate whether the MCA blood flow velocity measured by TCD changes after initial fluid resuscitation in septic ICU patients, and secondly whether this MCA blood flow velocity has the ability to accurately predict fluid…
The aim of this study is to find out whether TIG and revaccination prescription is in accordance with the immune status of a patient as measured by the TQS. Furthermore, the objective is to assess whether or not the TQS might be of additional value…
What is the proportion of STI outpatient clinic visitors with a persistent colonisation of chlamydia in the pharynx up until 3 weeks after the first diagnosis based on a NAAT positive chlamydia pharyngeal swab.
Objectives: 1) Describe the course of muscle SrO2 in patients with severe sepsis in relation to outcome and severity of disease 2) Describe the relationship between muscle SrO2 and serum lactate, SvO2, DO2 and VO23) Describe the course of cerebral…
The aim of this study is to estimate the seroprevalence of past C. burnetii infection among veterinarians working with livestock and to identify (coccupational) risk factors associated with Q fever seropositivity in veterinarians. This will give…
The objective of this study is to compare, evaluate and validate some commercial molecular diagnostic techniques for atypical respiratory tract infections. Simultaneously, we intend to define the most relevant clinical material per etiological agens…
To evaluate whether the 3M BacLlte system has a comparable sensitivity and specificity with the hitherto used conventional culture protocols
In case of food- or water related outbreaks of bacterial gastroenteritis, the regular research of Municipal Health Services (GGD) and the Food and Consumer Product Safety Authority (VWA) aims at control of the outbreak.The aim of this project is to…
Primary objective: To demonstrate that Positive Ct NAAT results 7, 21 and 49 days after (considered adequate) treatment of urogenital Ct with azithromycin is due to slow clearance of Ct RNA/DNA remnants (Ct culture negative) and not to therapy…
I.To assess the utility of point-of-care measurements of blood CRP and PCT levels to support clinical rules for diagnosing urinary tract infections UTI in nursing home residents.II. To develop and assess strategies that facilitate implementation of…