37 results
To estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially VAP, and to assess its association with patient-related and contextual factors, e.g. colonization status, serum antibody levels against S. aureus alpha toxin [AT],…
Objective of the study is to quantify the microbiological etiology in immunocompromised patients, at least 18 years of age, with CAP needing hospitalization. And to determine the severity, antibiotic use and outcome of CAP in immunocompromised…
To investigate the pathophysiological link between RA and PD, and test the efficacy of RvE1 treatment in gingival tissue biopsies of RA-PD and RA risk-PD patients ex vivo.
The aim of this research is to contribute to the understanding of the pathophysiology of severe infections, and subsequently providee relevant new insights in the development of new treatment modalities. In the present research proposal we would…
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…
Primary objectives:1. To determine the effect of the use of a tailored intervention protocol (regarding reduced antimicrobial use, improving hygiene and changing the animal contact structure) on pig and veal farms on the degree of antimicrobial…
Primary Objective: To investigate the presence of periodontitis in ACPA and or RF positive patients with arthralgia*s.Secondary Objective: to unravel the role of the cellular immune response in ACPA positive persons with arthralgia*s who are at risk…
To examine the effect of parasympathetic and sympathetic nervous system activity on the systemic innate immune response and the incidence of nosocomial infections in patients with vascular or traumatic brain injury. A second objective is to…
1. To investigate whether transmission of P. aeruginosa strains between CF patients occurs during a 1 day open air event and if so, whether there are patient-factors contributing to transmission. 2. To evaluate whether transmitted strains persist…
In previous studies we have identified specific receptor and surface protein expression profiles on neutrophils. Some of these profiles point at partially refractory neutrophils. In the current NERTHUS study we have seen that circulating neutrophils…
This study aims to identify qualitative and quantitative differences in innate, cellular and humoral immune response between persistent, intermittent and noncarriers of S. aureus.
Overall aim: to determine the extent and risk factors for farm-based and individual acquisition of Coxiella burnetii infections on ruminant farms to improve veterinary, occupational and public health by providing leads for primary (reduce…
To examine whether the use of systemically administered antibiotics in therapy resistant Lichen Sclerosus leads to:- Relief of symptoms- Improvement of clinical picture- Improvement of histological abnormalities- Effect on quality of life-…
Primary aimTo apply the CGT (intravenously and arterial sampling) in patient with multiple organ failure for the assessment of enterocyte function as a measure for intestinal (small bowel) barrier function.Secondary aimsTo compare the CGT with other…
The aim of the research is to enroll 100 consecutive untreated periodontitis patients for the normal standard treatment. We will investigate by means of venous blood analyses before treatment and 3, 6, and 12 months after treatement whether plasma…
1. estimate the prevalence of MRSA among calve farmers, their families and relevant co-workers at the calve farm;2. determine potential risk factors for MRSA carriage for these groups3. determine the association between MRSA prevalence and types of…
Primary objective:To determine the incidence of Clostridium difficile infection (CDI) in hospitalized patients aged * 50 years old and receiving oral or intravenous fluoroquinolones, cephalosporins, penicillins + beta-lactamase inhibitors,…
To study alteration in platelet function and RNA transcripts during and after a Gram positive and Gram negative infections.
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.