292 results
The primary objectives of this study are to evaluate the safety of 12 weeks of treatment with ABT-450/r/ABT-267 and ABT-333 with and without RBV, and to show the non-inferiority in SVR12 rates (the percentage of subjects achieving a 12-week…
investigate the relationship between il28b and apolipoproteine E genotype and response to interferon
The objective of this study is to gain insight into the occurence of mumps in a, presumed, highly immune student population, both clinical and subclinical mumps. Furthermore, there shall be an attempt to calculate the 'correlate for protection…
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In this study we will for the first time combine in-vitro stimulation assays and high throughput sequencing to identify, quantify and phenotype the clones that play a functional role in influenza infections and follow them over time. This will lead…
Primary:To evaluate the mass balance of the study medicationTo identify the metabolites of the study medication in plasma and excreta (urine and faeces)To identify the routes of elimination of the study medication in humansSecondary To assess the…
a. To assess the burden of mumps in the student population.b. To describe the risk factors for mumps virus infection (symptomatic and asymptomatic). c. To determine the relative contribution of household transmission and transmission at the party to…
Evaluate the prevalence, consistency, and genotype distribution of human papillomavirus (HPV) in semen and to examine the exact localization of HPV (i.e., in the seminal fluid and/or on the membrane or cytoplasm of the sperm cell).Evaluate the…
Measuring specific antibody titers against influenza A (subtype H1N1 and / or seasonal vaccine) in DS children. DS anti-influenza antibody titers will be compared with controls available from the same laboratory.
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.
Our hypothesis is: HBV interferes with the function of intrahepatic innate immune cells, especially NK cells. Since NK cells play a major role in anti-viral immunity and NK cells comprise a large proportion of the intrahepatic immune cells, we would…
Technical validation of HIV antibody detection in capillairy blood sampled with the Demecal set.
Primary Objectives: • To determine the basic immunity against influenza H1N1 (2009) in the population.• To determine the humoral and cellular immunity after a single vaccination with Influenza A virus (H1N1) 2009 Monovalent MF59- Adjuvanted Vaccine…
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
Determine if maximum doses of atorvastatin are safe in patients infected with chronic hepatitis C and if the so called pleiotropic effects of atorvastatin cause a decrease in the HCV viral load.
The primary objective of this trial is to provide early access to TMC125 for treatment-experienced HIV-1 infected patients who have failed multiple ARV regimens and have limited treatment options with the currently approved antiretrovirals.The…
testing and validation of the procedures for the collection and the transport to the laboratory of the sponsor in the US (VIRxSYS, Gaithersburg, MD) of PBMC's donated via leukapheresis by HIV-1 infected persons in the Netherlands and the…
1 To investigate the influence of HAART on CSF viral load, development of HIV resistance, neurotransmitters and biomarkers for neurodegeneration2 To explore the neurocognitive effects of HIV infection and its treatment3 To investigate the…
Primary objective: To evaluate if adequate exposure to ribavirin can be achieved after a dose adjustment based on the AUC0-4h from a first dose of ribavirin.Secondary:• To evaluate how many patients need a dose adjustment to achieve adequate…