29 results
Primary Objectives:To explore whether the decrease in a panel of early easily assessable biomarkers (PSA-mRNA, PCA3-mRNA and TMPRSS2:ERG gene fusion-mRNA, (currently under development) ARv7 mRNA, ARwt mRNA, miR-21, miR-141, miR-200a, miRrumc95,…
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
Can we identify a gene expression profile for late radiation toxicity?
The proposed project aims at implementing the available scientific knowledge for recommending biopsies or active treatment, respectively, at the individual level in Dutch urological practice. To this end we have developed an internet based decision…
Primary Objectives: a. Optimization of the 99MTc-HABN SPECT/CT scanning protocol in the first 5 patients (Phase 0). b. Detection and characterization of primary prostate cancer (tumor uptake and tumor-to-background ratio) in patients with 99MTc-HABN…
The primary objectives of this study are the following:• To evaluate the safety and tolerability of DMOT4039A when administered every 3 weeks or weekly to patients with unresectable pancreatic or platinum-resistant ovarian cancer• To determine the…
Primary Objective - To evaluate the time to PSA >4 ng/mL during the first cycle of IAD after the end of an induction period with degarelix (7 monthly treatments) in prostate cancer patientsSecondary Objectives - To evaluate the time to PSA .4…
Primary objectiveTo evaluate the effect of PK-guided individualized dosing of pazopanib on the interindividual variability in drug exposure.Secondary objective- To determine the correlation between pazopanib trough and exposure levels - To determine…
To study the toxicity, efficacy and immunogenicity of naked DNA vaccines encoding the shuffled HPV 16 E7 gene products (TTFC-E7SH) in advanced-stage patients with squamous cell carcinoma of the anogenital or the head and reck region.
To test in a prospective study the feasibility and outcome of low dose rate I-125 seed brachytherapy to treat early low risk prostate cancer in patients who have had previous TURP using specific recommendations on target and organs at risk dose…
To apply a novel blood assay to 150 patients undergoing a radical prostatectomy in order to assess whether this test can accurately identify indolent cancers and thereby prevent unnecessary treatments. To increase the accuracy of the flow cytometric…
The primary objective is to compare the sensitivity and specificity of tumour size and growth assessed with HistoScanningTM with the PRIAS parameters (PSA changes). The sensitivity and specificity of both methods will be measured with adverse biopsy…
To objectify and quantify patients ano-rectal complaints to identify the exact pathophysiology and involved anatomic structures. Following this, irradiation techniques can be developed or modified to selectively spare the abovementioned structures,…
The following objectives have been defined for PROCABIO:1. Integration of biomarkers in an updated and improved model for the prediction of indolent prostate cancer.2. Integration of biomarkers in the development of guidelines for efficient…
To quantify the motion of the seminal vesicles.
To investigate if contrast enhanced ultrasound can improve prostate brachytherapy outcomes. Besides that we will investigate if contrast enhanced ultrasound can be used as an extra verification of follow up after treatment.
The primary objective of the present study is to obtain insight into the long-term effects of EC and new treatment strategies on HRQL in a population-based setting. Therefore, we will assess HRQL among 2 to 9 year survivors of stage I or II EC…
The first objective of this study is to test the hypothesis that a higher dose to the IPAs and corpora cavernosa is correlated to ED after EBRT. The second objective is to test the hypothesis that RIF in the IPAs and corpora cavernosa is correlated…
This study will investigate a comparison group of women treated with a conventional (non-nerve sparing) RHL for cervical cancer (CC) at the Academic Medical Centre (AMC). Together with the data collected of women treated with a nerve sparing radical…
Primary Objective: * To evaluate the ability to concentrate the radiotracer within the prostate gland improving the evaluation of the primary prostate tumor. Secondary Objective(s): * To evaluate the PET/CT imaging characteristics of transcatheter,…