52 results
The primary objective of this study is to estimate the incidence of ocular adverse events in patients with CNV secondary to AMD who receive an individualized treatment with ranibizumab 0,3 mg.
The aim of the study is to measure RT (central, peripapillary and peripheral) in normal subjects and study the posibillity to reduce the variabillity of this measurements by normalisation. Futhermore, correlation of RT with axial lenght, gender and…
Evaluating the long term safety and tolerability of ranibizumab treatment of AMD patients.
To determine the natural history and long term (10 years) outcome of CSR.
What is the contribution of the different variations in the C1-inhibitor gene to the disease AMD?
Quantification of the incidence of postoperative CME in DSAEK patients.
To measure the test-retest and inter-chart reliability of the Dutch version of the Radner reading chart in an older population with maculopathy.
By observing several visual aspects in a large patient population we would like to obtain more information about the best time of surgical intervention (primary study group). 80% of the patients need only one surgical intervention to obtain an…
Primary ObjectivesThe primary objectives of this study are:* To evaluate the long-term efficacy outcomes following short-term exposure to rhIGF-1/rhIGFBP-3 versus standard neonatal care in Study ROPP-2008-01 (Section D) as assessed by ROP associated…
Long-term follow up of patients treated with limited PDT, for a symptomatic circumscribed choroidal hamangioma, in search of possible late unwanted side effects of PDT treatment and recurrence of leakage.
To investigate if E-PsEYE leads to a reduction in depression and anxiety symptoms (primary outcomes) and problems with adaptation to vision loss(secondary outcome). Conducting a process evaluation to determine adherence and patient satisfaction. To…
To gain insight into the incidence of retinopathy and optic neuropathy in relation to the radiation dose in order to develop a normal tissue complication probability (NTCP) model for the eye and the optic tract.
This study will evaluate the long-term safety and tolerability of IVT faricimab in patients with nAMD who have completed either of the Phase III (GR40306 or GR40844) studies. Additional assessments relating to efficacy, pharmacokinetics,…
The goal of this study is to characterize the natural course of IRDs that can potentially be modulated by future therapy. Second, this study aims to understand the relationship between various structural and functional biomarkers in potentially…
This extension study aims to collect long-term data on safety and efficacy in a subject population treated for ROP with aflibercept and/or laser, and to contribute to the clarification of potential effects.
To collect data in order to create a registry that can be used for research in PXE, partly with an international questionnaire, and to measure PPi, ENPP1 activity, anti-retinal antibodies and cytokines, and retinal calcification in all patients…
Our study objective is to investigate the reliability of commonly used clinical examinations and endpoints performed in patients with inherited retinal dystrophies in anticipation of future clinical trials.
To determine whether functional and/or structural retinal biomarkers or circulating biomarkers are able to differentiate people with mild cognitive impairment (MCI) within the type 2 diabetes (T2D) population (this we will be able to do in the…
Objective: To collect a broad array of clinical, behavioural, physical and biochemical parameters, to ensure that many clinical research questions or problems related to successful aging with T1D can be answered. Nevertheless, we have a priori…
The primary objectives of this study are the following:* To prospectively characterize CEP290-related retinal degeneration and the clinical phenotype of participants with light perception to 20/50 visual acuity and with either compound heterozygous…