66 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
To identify novel diagnostic and prognostic (bio)markers of Dementia with Lewy Bodies.
to evaluate the feasibility and usability of a brief dementia screening instrument for primary care setting
The objectives of this study are as follows:1) To determine the sensitivity and reproducibility of novel assays developed at the Janssen Prevention Center to detect anti-tau immune responses in the blood of individuals.2) To determine the…
To determine the prevalence of pruritus and pemphigoid in nursing home patients.To assess the relationship of demographic and medical risk factors with pemphigoid in nursing home patients.To assess the association between pruritus and…
The primary objective is to assess the effects on amyloid plaque burden of administration of VX-745 for 12-weeks, as assessed by Dynamic 11C-PiB (Carbon-11 labeled Pittsburgh Compound B) PET Amyloid Scanning in patients with Mild Cogntitive…
Primary objectives: To evaluate the long-term safety and tolerability of IV administered bapineuzumab in subjects with AD.Secundary objectives: Efficacy. To explore the long-term efficacy of IV administered bapineuzumab in subjects with AD, using…
To further develop the dignity model in the nursing home setting by assessing which factors are especially relevant to dignity in this setting. The specific objective of this substudy is to develop a valid and reliable measurement instrument to…
Primary objectives: To evaluate the long-term safety and tolerability of IV administered bapineuzumab in subjects with AD.Secundary objectives:To explore the long-term efficacy of IV administered bapineuzumab in subjects with AD, using the following…
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
Overall aimThe ultimate goal of our studies is to optimize treatment and reduce treatment related complications in patients with diabetes and cognitive impairmentOur specific objectives are to:1. assess the validity of two self-administered…
Objective of the project is to the American EDDI translate and adapt to the Dutch situation. Then, in a pilot study there will be examined whether the intervention is applicable to people with dementia and their caregiver, and if so, under what…
The goal of this research project is to develop a multidisciplinary guideline for the responsible and restrictive treatment of freedom restriction in the care for elderly with dementia and people with intellectual disabilities. In this guideline the…
The primary objective is to examine the relationships between the cognitive tests results of the neuropsychological assessment and dual-task cost in elderly with cognitive impairment. The second objective is to examine differences in gait…
The general aim of this study is to explore how a motivational deficiency (i.e. apathy) related to neurodegenerative diseases is associated with effort and how it can be distinguished from intentional underperformance. We will investigate whether…
To assess the effectiveness of Socially Assistive Robot (SAR) interventions involving one specific SAR, the Paro system.
Investigate the degree of association between the level of AGE*s and the development and progression of paratonia in Alzheimer*s Disease (AD).Research questions are:(1) Are elevated levels of AGE*s, at baseline and during 12 months follow-up,…
In the present project we aim to develop a first working platform for interactive, home-based blood pressure screening and monitoring by using internet and smartphone technology in middle-aged offspring of patients with dementia.
Safety-evaluation in case of long term daily usage of MPC-7869. In this Open Label Study , with regard to the safety of MPC-7869, attention will be paid to the amount of AE*s, the physical examinations of subjects, the research of vital functions,…