66 results
The aim of this study is to evaluate the additional value of quantitative amyloid imaging analysis for modelling and assessing Alzheimer*s Disease (AD) dementia risk in individuals without dementia, compared to a range of existing cognitive, imaging…
Primaire Objective: - To evaluate the safety and tolerability of long-term treatment with the study drug in patients with ALS or FTD with a documented mutation in the C9orf72 geneSecondary Objective: - To evaluate the clinical and pharmacodynamic (…
Primary Objectiveo evaluate the safety and tolerability of a one-time, intrathalamic administration of AVB-101 in subjects with FTD-GRN.Secondary Objectiveo To evaluate the preliminary clinical and biomarker measures of efficacy of a one-time,…
This study aims to add the new ASL MRI sequence to the scanning protocol of the Centrum voor Ouderengeneeskunde Amsterdam (COGA) study (METC number 2017.148), to study the BBB integrity of the subjects included in the COGA study.
The primary objective of the SCIENCe project is to establish a prospective cohort of patients with subjective complaints, to study the earliest brain changes ultimately leading to cognitive decline and dementia due to AD. Specific research questions…
Our overall aim is to study how different pathological mechanisms in cerebral SVD influence WMH shape.Primary objectiveTo study the association of a more complex WMH shape with abnormalities in small vessel morphology.Secondary objectiveTo study the…
Primary:• To evaluate AD-specific, neuroinflammatory, neurotrophic and neurodegenerative biomarkers and safety of 3 intrathecal (IT) administrations of NurOwn® (MSC-NTF cells) given at two monthly intervals to participants with prodromal to mild…
The purpose of this study is:To investigate how glutamate is processed in the brain using magnetic resonance, a non-invasive technique used to see images of your brain. Glutamate is a chemical that sends signals between nerve cells in the brain.
This study (AMYPAD Diagnostic and Patient Management Study) will determine in a real-life clinical setting for whom diagnostic amyloid PET imaging is appropriate, when this is best performed, and how the resulting information is influencing…
2.2 Primary ObjectiveTo study clinical factors, (blood) biomarkers and genetic markers related to AF progression in patients diagnosed with recent onset self-terminating AF with special reference to hypercoagulability.2.3 Secondary Objectives1. To…
The primary objective is to determine the safety, tolerability and preliminary efficacy of repeated intrathecal administration of NurOwn® (MSC-NTF: Autologous Mesenchymal Stem Cells [MSC] Secreting Neurotrophic Factors [NTF]) given three times at…
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
The purpose of this research is to determine the usability of a wearable regarding the care of people with dementia showing challenging behaviour in a nursing home (geriatric psychiatry department). The relationship between biomedical data and…
1. To provide a well-phenotyped population (readiness population) for the EPAD PoC trial to minimize trial screening failures 2. To provide a well-phenotyped probability-spectrum population for developing and continuously improving disease models…
The main objective of this study is to predict the rate of decline for both motor and cognitive function in an existing PD patient cohort using a combination of baseline CSF and blood biomarker profiles (T0). The secondary objective is to determine…
This study has been transitioned to CTIS with ID 2024-518865-85-00 check the CTIS register for the current data. Primary objectiveEvaluation of [18F]MC225 to measure the P-glycoprotein function in Alzheimer*s disease, Mild Cognitive Impairment and…
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
The main objective of the study is to examine whether dynamic light has a positive influence on the sleep-wake rhythm, depression, emotional distress and agitation in people with dementia. Healthcare innovations, intended for at home use, are used…
The objective of this study is to evaluate the acute effects of sitting on cognitive measures in healthy elderly, and if these effects can be prevented by breaking-up sitting and/or a high mental activity state. In addition, this research explores…
The objective is to investigate how dementia affects processing of pain. More precisely, we aim to investigate how dementia-related neurodegeneration (occurring in Alzheimer disease (AD), frontotemporal dementia (FTD) and vascular dementia (VD))…