19 results
First objective: gain insight in the coordination of trunk, head and arm during functional tasks in healthy children and compare this with the coordination in children with DMD, SMA and CP. Second objective: investigate if newly developed supportive…
•To characterize the natural history and progression of DMD to help inform the design of future studies•To capture biomarkers of safety and disease progression•To provide comparative data for the development of rare exons for which formal controlled…
Within this complete European consortium animal models as well as patient material are utilized, in order to uncover the pathogenic pathways in OPMD that are at the centre of the disease, eventually in order to design rational evidence based…
The objective of the study is to be able to determine the contribution of blood inorganic phosphate to the signal observed in skeletal muscle.
To investigate the effects of three different methods of finding a suitable recording site for CMAP and three different electrode sizes on CMAP amplitude and its reproducibility
Main objective Because this study will include young children (0-3 years old) the challenge is to measure isometric muscle force adjusted to their natural behavior. From 4 months old a child can pull a toy towards himself. Therefore we want to use…
1. Assessment of sensitivity of several outcome measures in muscle force and function in Duchenne muscular dystrophy2. Assessment of reproducability of different outcome measures3. Assessment of clinical relevance of measured change over time in…
To determine the feasibility and applicability of the intervention 'Traject' to improve the participation in work of young adults (16-25 years) with a chronic disorder.
To investigate if difference in fiber type and/or oxygen supply are the underlying cause for the difference in PCr recovery along the length of the tibialis anterior muscle.
In this study we will assess whether the application of daily blood flow restriction during 2 weeks of bed rest will attenuate losses in skeletal muscle mass and strength. With measurements, before, during and after the bed rest period, we can…
The primary objective of this study is to evaluate the safety and feasibility of 3 months martial arts based training program for DMD patients. The secondary objective is to gain a first impression on the program*s ability to optimally use one*s…
To compare the anabolic properties of a meal-like amount (40 g) plant-based protein when compared with animal-based protein on muscle protein synthesis rates in vivo in humans.
To assess whether co-ingesting keto-analogues of branched-chain AAs along with protein during HD can attenuate HD-initiated muscle catabolism.
The primary objectives are to:1) Adapt and optimize sequences and protocols to enable acquisitions during exercise with MRI and/or surface EMG.2) Perform a study in healthy volunteers using the sequences and protocols developed in 1) to correlate MR…
The aim of the Survey is to better understand the variability and progression of Pompe disease and to continue to monitor and evaluate the long-term effects of available treatment options and support measures including ERT with alglucosidase alpha…
With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…
In this exploratory study we aim:1) To identify the confounding factors in qMRI analysis (e.g. age, gender, body composition)2) To determine the relation between qMRI parameters and muscle force and function taking into account the confounding…
The primary objective is - To clinically validate the inter-observer reliability of compressibility measurements with the CPM#1 device during rest in healthy volunteers.
Primary objective• To characterise natural disease progression rates of MRI- and/or US-assessed measures of muscle properties and muscle function and strength tests in children with neuromuscular disorders through standardized annual follow-up…