21 results
To investigate the impact of 7 days of bed-rest on skeletal muscle mass, strength and whole-body insulin sensitivity in healthy, young men.
To identify predictors for the different treatment options for obesity (1. combined lifestyl intervention plus, 2. E-health treatment, 3. bariatric surgery; inclusion for treatment options 1 and 2 takes place in the EMC, inclusion for the treatment…
The objective of this pivotal study is to assess the long-term safety, tolerability, pharmacokinetics and pharmacodynamics of RP103 in pediatric and adult patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support…
To study feasibility, reliability and validity of a specific set of outcome measures in children with mitochondrial myopathy.
Primary objectiveTo measure the conversion rate of mono- and disaccharides into oligosaccharides and mannitol in the digestive tract by the action of food grade micro-organisms Secondary objectivesTo measure pH of gastric and duodenal fluids at…
To investigate the acute effects of capsaicin on energy expenditure, substrate oxidation, appetite profile and ad libitum energy intake during negative energy balance.
The first aim of this study is to extend clinical knowledge on NPC. This has several reasons:1) The heterogeneous clinical presentation of NPC makes extensive clinical knowledge amongst physicians a prerequisite in preventing diagnostic delay.…
To determine ad libitum daily energy intake, energy balance and appetite profile in response to protein/carbohydrate and fat ratio over 12 consecutive days, and in relation to age, gender, BMI and FTO polymorphisms.
To study the application of fMRI for the detection of BAT perfusion.
To determine ad libitum daily energy intake in response to protein/carbohydrate and fat ratio over 12 consecutive days, and in relation to age, gender, BMI and FTO gene alleles.
To determine energy expenditure and sleep in response to protein/carbohydrate and fat ratio of the diet over a short-term and long-term period of time.
1. To determine the nature and time course of the energy sensing machinery during starvation in humans.2. To correlate systemic adaptations with changes at the cellular level.
In this study, we will investigate the use of optical spectroscopy in determining neonatal bilirubin and hemoglobin blood levels. The outcome and accuracy of the optical spectroscopy measurements will be compared to the outcome of laboratory blood…
To anwer the question: Is the elevation of energy expenditure and mitochondrial uncoupling smaller in obese than in lean subjects after mild cold exposure and what is the role of the sympathetic nervous system?
The objective is to study whether saturated fatty acids induce a different postprandial change in inflammatory markers than cis-polyunsaturated fatty acids.
To characterize the natural history and clinical management of AHP patients with porphyria attacks.
To investigate whether a tailored physical activity program that starts early (during curative chemotherapy with cardiovascular toxic potential) is superior in terms of reducing long-term cancer-treatment-related metabolic syndrome and…
Studies of ex vivo muscle cell autophagy flux, leucocyte mitochondrial function and oxylipins, specifically prostaglandin E2 (PGE2) in critically ill patients during admission to an intensive care unit (ICU).
This study has been transitioned to CTIS with ID 2022-502492-32-00 check the CTIS register for the current data. PrimaryPart I: Evaluate the safety and tolerability of mRNA-3705 administered via IV infusion to participants with isolated MMA due to…
Primary Objectives: Safety Assessments: Effect of Administration of Relacorilant on: • Incidence of TEAEs (assessed monthly): TEAEs, SAEs, treatment-related TEAEs, TEAEs leading to early discontinuation of study treatment• Clinical laboratory tests…