362 results
The main objective of this study is to demonstrate treatment efficacy of MR-HIFU ablation of breast cancer. Effective treatment is defined as 100% necrosis of the targeted primary breast tumor. The secondary objective is safety of the MR-HIFU…
1) What is the variation in follow-up care practice since 2011 for cervical cancer patients?2) What physician-, patient- and informal caregiver -factors are associated with differences in follow-up care schedules? Regarding patient/ informal…
Primary: * To assess Clinical Benefit Rate (CBR) in patients with mCRPC and poor prognostic factors treated with cabazitaxel or novel hormonal agents (abiraterone OR enzalutamide) as second-line therapy.Secondary: * To formally compare CBR in both…
Improving fertility preservation counseling by gynaecologists by providing more insight in important ascpects for patients regarding fertility preservation trough autotransplantation of cryopreserved ovarian tissue.
The primary aim of this study is to assess the overall, and treatment arm specific, gonadotoxic potential of the protocol in both boys and girls treated for classical Hodgkin Lymphoma in Europe. Secondary aim is to evaluate the frequency of various…
This study has been transitioned to CTIS with ID 2024-516781-10-00 check the CTIS register for the current data. Primary objective:• Systemic immunogenicity of the DCP-001 vaccination in high grade serous ovarian (HGSOC) cancer patients.
This study is conducted to discover if bacterial vaginosis is related to the pregnancy rate in couples undergoing assisted reproduction.
To investigate the technical feasibility of inserting a brachytherapy needle into the prostate to a defined tumour target point using a robotic device.
1. Evaluation of the variation of semen characteristics in the general population2. Evaluation of the variance of testosterone levels in the general population
The primary objective of this study is to prove feasibility and safety of TPLA for LUTS due to BPO in healthy men. The secondary objectives are to determine functional voiding, erectile outcomes and changes on imaging.
Aim of the Study:This prospective, single-arm study is to evaluate the mid-term efficacy and safety of the Calistar S pelvic floor repair system for prolapse repair.
The aim of the NEtherlands Chlamydia Cohort STudy (NECCST) is to assess the risk of developing complications and the time to pregnancy in women with and without a known previous Ct infection. Furthermore, this study aims at determining host genetic…
This study has been transitioned to CTIS with ID 2024-518985-29-02 check the CTIS register for the current data. To prospectively investigate if a treatment strategy in which two types of cytotoxic RLT, i.e., an alpha-emitter and a beta-emitter, are…
This study has been transitioned to CTIS with ID 2023-505455-44-00 check the CTIS register for the current data. Part 1 (phase 1b)Primary:• To observe the safety and tolerability of bemarituzumabSecondary:• To evaluate preliminary antitumor activity…
This clinical performance study will evaluate the effectiveness of the Ki 67 IHC MIB-1 pharmDx (Dako Omnis) to identify estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- early breast cancer patients whose tumours score Ki-67…
Determine AYA*s experiences and needs related to FP(C) and follow-up care after FP(C) (Q1); determine the number of AYAs pursuing to conceive and their fertility and obstetric outcome(s) after FP(C) after gonadotoxic treatment (Q2); determine…
Primary Objective: To study the effect of different treatment approaches - existing of conservative management, pharmacological treatment and surgical treatment - on sexual function in patients diagnosed with endometriosis. Secondary Objective(s):…
The primary objective is to demonstrate non-inferiority of the detection rate of clinically significant prostate cancer (defined as GG>=2) in targeted biopsies based on PGaVision imaging (PCaVision pathway) in comparison with the detection…
The ultimate objective is to optimize pessary treatment for all patients with pelvic organ prolapse (POP). To reach this goal, we need to learn more about the mechanisms behind success and failure of pessary treatment. Previous research suggested…
This study aims to be the first to visualise changes in both clitoris and pelvic floor musculature following testosterone administration and to explore how these changes relate to sexual function. The primary objective of this observational study is…