204 results
Investigate the degree of association between the level of AGE*s and the development and progression of paratonia in Alzheimer*s Disease (AD).Research questions are:(1) Are elevated levels of AGE*s, at baseline and during 12 months follow-up,…
To determine if a Parkinson*s patient can operate a test inhaler correctly during off periods, by testing if they can generate a sufficiently large airflow and volume through the test inhaler theoretically necessary to disperse a medicinal powder…
To test the suitability of the PortaLite fNIRS device for measuring brain activity during dual tasking performed by elderly with Parkinson*s Disease (PD) and design a valid and feasible protocol for this measuring.
The aim is to further track the course of motor symptoms and functional status, and to establish conversion to Parkinson*s disease dementia (PDD).
To assess whether there are differences (including sensitivity and specificity) in pen motion and grip force patterns, derived using a system for handwriting monitoring while performing different writing, tracing and fine motor skill tasks, between…
To gain experience with a fine-wire intramuscular measurement technique for recording of short-latency muscle responses in neck muscles.
The aim of the study is to show safety and effectiveness of the Sapiens electrode in an acute, intra-operative setting.
The primary objective of the proposed feasibility study is to determine the willingness of patients to be randomized to CLI or DBS. Furthermore it will serve as a pilot trial for a future larger randomized controlled trial. For this larger trial,…
The present proposal comprises the combination of aforementioned techniques to study reflex modulation by the CNS of peripheral reflexes. The influence of careful timed TMS pulses on the contralateral sensorimotor cortex of healthy subjects on EMG…
The primary objective is to avoid cognitive and affective side effects and maintain the beneficial motor effects by selective stimulation of the STN motor part. With the Select Stim project we want to improve the classical operation procedure, in…
The development of a valid and reliable test intended to measure functional motor activities in daily life of children with DCD.
To gain insight in the cognitive basis of the positive effect of apomorphine on visual hallucinations in Parkinson's disease (PD)
The aim of this study is to determine objectively and quantitatively the relationship between different stimulation settings, in different nuclei (the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi)) and the degree of…
The main goal of the proposed experiment is to provide evidence for the hypothesis that the adaptation range of posture control behaviour with only proprioceptive feedback is similar to the adaptation range with visual and tactile feedback also…
Primary aim of the study is to evaluate the efficacy and safety of intramuscular magnesiumsulphate in CRPS I patients during 3 weeks dose escalation study.
In the present study, we investigate the role of the STN in different conditions.In earlier research, we found that the STN is involved in response selection and inhibition. This was investigated using behavioral measurements. Currently, we want to…
To investigate the value of ancillary diagnostic investigations, more specific MRI, 123I-MIBG scintigraphy, ultrasound examination of the basal ganglia and analysis of cerebrospinal fluids to differentiate Parkinson's disease and the Atypical…
In the proposed experiment we expect to find a similar functional segregation within prefrontal and premotor cortical regions when a free choice option is introduced.
The primary objective of this test series will be to gain experience and provide long-term safety using a transcutaneous titanium port as an access port for gastrostomy (T-Port) in the context of Duodopa treatment of severely afflicted PD patients.
The aim of this pilot study is to evaluate whether precise HDsEMG-guidance improves the therapeutic effect of BTXA. Because of its minor functional importance and focused endplate distribution, the extensor digitorum brevis (EDB) muscle is selected…