204 results
To evaluate the responsiveness of the extensor digitorum brevis (EDB) muscle to BoNT/A in extremities affected and unaffected by CRPS.
The objective of the study is to investigate the changes in cortical connectivity patterns, as measured by resting-state fMRI, as a consequence of the use of transcranial direct current stimulation.
To include Dutch subjects in a Canadian study to establish the frequency of intergenerational CAG size changes for individuals with an intermediate allele (27-35 CAG) for Huntington disease. This will allow us to understand the evolution of HD…
The primary objective of this study is to analyze the frequency and severity of fatigue in patients with spinocerebellar ataxia and to test whether duration of the disease, depression and the severity of ataxia are related to the severity of fatigue…
The primary objective of this study is to assess the reliability and validity of the most commonly used anxiety rating scales in PD within one year. In the event that none of these scales has satisfactory clinimetric properties, additional…
1. To determine whether AFO stiffness can be optimized for individual patients in terms of minimizing the energy cost of walking. 2. To asses whether the optimal AFO in terms of energy cost of walking matches the AFO at which the most energy can be…
We aim to experimentally evoke FOG in patients walking on a motorised treadmill, using either expected or unexpected obstacles, or changes in visual feedback of gait
To demonstrate the likelihood of the motor causes of drooling in PD: reduced swallowing frequency (akinesia), open mouth and mouth breathing (rigidity), reduced swallowing capacity (hypokinesia) and stooped posture.
To investigate the effects of galantamine on cognitive impairment and visual hallucinations in Parkinson`s disease, both therapeutic (direct effect) and preventive (protection against an acute increase of dopaminergic medication used by the patient…
Since obstacle avoidance is impaired in PD, with the inability of the patient to regulate both cadence and step length before crossing the obstacle, we wonder what the effect of controlling cadence (by means of a metronome) will be on the pattern of…
The ultimate goal is to build a large, well-documented, database of normal FP-CIT data obtained in healthy volunteers. For this purpose, in a large number of European institutes we will obtain in, minimal 10 and maximal 15 healthy volunteers per…
To examine the effect of tizanidine on the system characteristics of the reflex in the upper extremity
To determine the feasibility and applicability of the intervention 'Traject' to improve the participation in work of young adults (16-25 years) with a chronic disorder.
Collecting normal values of I-123-FP-CIT uptake with SPECT in striatum relative to occipital cortex uptake in heathy volunteers
The goal of the entire PhD project is to find the motor part of the STN using advanced image acquisition and image analysis. To reach this eventual goal, we first have to be able to visualize the STN as a whole. Published studies show only 2D-images…
Primary aim of the study is to compare the efficacy and safety of two flowrates of ITB while maintaining a constant daily dose.
The aim of the study is to gain insight on the somatotopy of the subthalamic nucleus. The relation between the postion o fthe electrode in the STN, the parameter settings of the stimulator and the effectiveness of the stimulation on Parkinson's…
To assess the validity, reliability and feasibility of accelerometers and the Pedar Mobile system for measuring balance during standing and walking of patients with neurological and vestibular disorders.
Evaluation of the effect of deep brain stimulation on the dopamine household in Parkinson*s disease.
The present study proposal could be able to provide an answer to the following questions:1) what is the effect of the oral administration of levodopa on the synaptic dopamine concentration in end-stage Parkinson*s disease?2) how does microlesioning…
The design of an ambulant system that is capable of long-term estimation of the right UPDRS-levels for tremor, bradykinesia, and akinesia in patients with Parkinson*s disease receiving deep brain stimulation in the subthalamic nucleus using a…