124 results
to investigate the analgesic effect of high frequency 10 Hz rTMS on experimental pain measured through quantitative sensory testing (QST) in healthy subjects.
Primary objective of this study is to assess the acute dose dependent effects of single doses of oxazepam (10 mg and 30 mg) on driving performance and compare it with a single dose of diazepam 10 mg and placebo.
To compare the digestion and absorption of micellar casein versus calcium-caseinate and sodium-caseinate with enzymatic cross-linking in healthy young men.
To determine the effect size of three different doses of PRM-151 on reduction in bone marrow fibrosis by * 1 grade in intermediate-1, intermediate-2, and high risk subjects with PMF, post-PV MF, or post ET-MF who are anemic or thrombocytopenic and…
The primary objective of this study is to compare the acute effects of single doses of methadone (5 and 10 mg) and buprenorphine (0.2 and 0.4 mg) with placebo on driving performance and cognition. Secondary objective is to study the pharmacokinetics…
The aim of this study is to objectively assess 3D and functional outcomes of upper blepharoplasty on periorbital volume, dry eyes, peripheral vision, electrical activity of the frontal muscles and wellbeing in two different surgical techniques.
To compare the plasma amino acid responses after the digestion of a milk protein powder with varying levels of protein glycation in healthy young men.
Aims of this in situ study are: i) to investigate whether there is a threshold in gap size for secondary caries to develop and additionally to link the level of secondary caries formed with the caries risk of the volunteers, and ii) to evaluate the…
Hypotheses: - Ileal delivery of casein and/or sucrose induces stronger effects on satiation compared to placebo- Ileal delivery of casein induces stronger effects on satiation than ileal fat delivery- Ileal delivery of sucrose induces stronger…
We propose to conduct a study in healthy young and elderly subjects and patients diagnosed with mild to moderate AD, FTLD, or DLB where cholinergic and serotonergic challenges are given in a placebo-controlled, crossover fashion. Before each…
1) To investigate the effect of atomoxetine on resting-state fMRI measures of network functional connectivity.2) To assess the effect of atomoxetine on several task performance variables, that are hypothesized to reflect tonic LC-NE activity.3) To…
The primary objective of this study is to assess if cannabinoids modulate sweet taste intensity and liking.
To determine whether a single dose of 50 IE/Kg PCC is effective in reversing the anticoagulant effect of Dabigatran Etexilate 300mg b.i.d. taken for 2.5 days, as assessed by two modified skin bleeding assays: the "shed blood" and "…
Primary Objective: to ascertain whether administered clonidine and scopolamine affect performance (as measured by modulation of reaction times, learning and/or error rates) in a range of cognitive tasks designed to examine uncertainty estimation and…
The main objective of the present protocol is to investigate to what extent oxytocin modulates specific aspects of interpersonal approach, mimicry, and communication in healthy volunteers with varying degrees of social anxiety.Results from this…
To assess exogenous and endogenous carbohydrate oxidation rates during prolonged (3 h) endurance-type exercise (Part A) or muscle glycogen repletion following exercise (Part B) while ingesting glucose-only, or glucose plus fructose or glucose plus…
To evaluate the plasma pharmacokinetic properties and safety of the research medication in healthy volunteers and in Patients with Systemic Mastocytosis and Allergic Asthma.
We aim to compare the clinical performance of zirconia stock and CAD-CAM produced implant abutments (experimental group) after one year of function. After one year, the abutments and crowns are removed and subjected to a static bending test in vitro…
The primary objective of the study is to examine the changes in core body temperature during a 60 minute cycling exercise bout at 85% of maximum predicted heart rate using double blind placebo or paracetamol in a group of healthy young subjects.
The objective of the study is to test the effects of the p-glycoproteine transporter on cognitive test in healthy volunteers and to explore the effects of the p-glycoproteine transporter on functional Magnetic Resonance Imaging (fMRI).