28 results
The projects is divided in 3 aims: 1) To evaluate the regenerative capacity of lung-derived MSCs (LMSCs) from normal and emphysematous lung tissue and compare LMCSs to MSCs derived from other tissues2) To investigate the interaction of MSCs with the…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
Primary objectives of the pilot study• To determine childhood cardiovascular health in offspring of PCOS mothers and to compare it with children from non-PCOS mothers.Secondary objectives of the pilot study• To compare cardiovascular risk factors…
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
Evaluate the effect of intrathoracic pressure on right ventricular function in healthy subjects.
The primary aim of this project is to define the role exacerbations play in the pathophysiology of COPD. Moreover, the study has the aim to determine the long-term effects of PR and the natural course of the disease. The unique design of MCC will…
Intestinal Permeability during Respiratory insufficiency in patients with acute exacerbation of COPD
The primary objective of the present study is to investigate if the intestinal permeability is increased in patients with an acute COPD exacerbation. To investigate this objective, the following research question have been formulated:- Is intestinal…
The general objective of the Doetinchem Cohort Study is to contribute to the answering of public health questions, now and in the future, by providing basic data on developments in lifestyle and health problems in the general Dutch population.
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
The aim of this study is to investigate if there are genetic factors predisposing to Löfgren*s syndrome, and whether these factors have an influence on the clinical course.
To examine the apoptotic response of isolated and cultured airway epithelial cells of infants to a wide variety of cytotoxic agents and potential apoptotic stimulants ex vivo. These include oxygen, nitric oxide, peroxynitrite, cigarette smoke…
To measure markers of several pathways of apoptosis in broncho-alveolar lavage fluid in time during MV in children.
In this pilot study we intend to measure Tregs in umbilical cord blood, in normal as well as in pregnancies complicated by preeclampsia, and will define their use as a predictor of the risk for developing allergic diseases in the child.
To investigate the occurrence and burden of morning symptoms in outpatients diagnosed with COPD gold II-IV.
The primary objective of this study is to determine the eosinophil lifespans under inflammatory conditions in the blood and lungs of patients with eosinophilic asthma
1. To predict the clinical course (in terms of occurrence of ALI and ARDS, duration of mechanical ventilation, need for renal replacement therapy, length of ICU-stay, length of hospital-stay, ICU-mortality, 30-day mortality) in patients after…
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…