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Identifying the determinants of the long-term prognosis of Obsessive Compulsive Disorder.

The AMSTAD-OCD study aims to contribute to the improvement of outcome in OCD by identifying the determinants of a chronic course.

Omega-3 fatty acid supplementation and the recovery from anorexia nervosa and comorbid depressive and anxiety problems: a pilot study

To draw definite conclusions about the effectiveness of omega-3 PUFA supplementation in anorexia nervosa patients a double-blinded, placebo-controlled randomized controlled trial (RCT) with a substantial sample size should be conducted. Prior to…

The effect of micellar curcumin (Espera C®) on the molecular immune signature of pancreatic cancer patients.

To determine whether micellar curcumin is able to restore functional lymphocytes in pancreatic cancer patients with stable disease after standard of care treatment.

Detection of pituitary neuroendocrine tumor (PitNET) tissue during endoscopic transsphenoidal surgery using Bevacizumab-800CW: a single center feasibility and dose finding study

The primary objective of this study is to determine the feasibility of intraoperative fluorescence imaging detection of PitNET tissue during TSS using the VEGF-targeting optical agent bevacizumab-800CW in tumors with a Knosp grade of 3 or 4.…

KNee osteoArthritis anterior cruciate Ligament Lesion study

10 years ago we selected an unique cohort of 154 patients with acute ACL injuries, who were prospectively characterized over the first two years post-injury. A single follow-up measure within this established cohort is proposed, to those that gave…

A Phase 1, Open-label, Single-dose, Randomized, Crossover Study to Assess the Local Tolerability of the Tildrakizumab 200 mg Dose when Delivered as Single Subcutaneous Injection via the 200 mg/2 mL Pre-filled Syringe

The purpose of this study is to investigate how well a new dosage form of tildrakizumab is tolerated when it is administered to healthy volunteers. Tildrakizumab (also known as Ilumetri) is no new compound; it is already available on the market as a…

Exploration of the effects of high frequency stimulation induced secondary hyperalgesia on the NDT-EP method.

The primary objective of this study is to investigate the quality and content of the MTT-EP model in response to electrocutaneous stimuli by determining stimulus-related and/or physiological-related components, before and after the occurrence of HFS…

Heart rate registration in neonates using a PPG-integrated cap

Primary Objective: To assess the agreement between the heart rate assessed with a dedicated cap with integrated PPG-leads and standard ECG monitoring using regular neonatal thoracic electrodes as reference technique.Secondary objectives:Does…

*Exploring cytokine detection in the stratum corneum of psoriasis patients by two noninvasive methods: sampling by TAPE and Transdermal Analysis Patches (TAP).*

(I) To compare patient friendliness in adult psoriasis patients between two non-invasive cytokine detection methods: TAP and TAPE. (II) To assess the correlation in cytokine detection by TAP and TAPE stratum corneum sampling in psoriasis patients.

Resmon Pro Diary Pilot Study - Evaluation of Vivisol Service to remotely prevent COPD exacerbations

This pilot does not aim to demonstrate the effectiveness of the system. The effectiveness of the system has been demonstrated in the recently published study: Chromed study, a multi-center Randomized Controlled Study.This pilot aims to obtain…

T-cell activation in high lipoprotein(a) patients

To assess T cell activation in patients with extremely high Lp(a) levels versus controls with low Lp(a)

Exploring the measurability of co-responsibility over time and in context, via design interventions

This study has a strong explorative and qualitative approach and set-up. Please note that the goal of the study is to further identify possible areas for innovation for professionals, patients and their partners. The aim for this study is NOT to…

Identification of sentinel lymph nodes in breast cancer patients through non-invasively and percutaneously fluorescent imaging using ICG

In this non-inferiority study, we aim to identify the diagnostic value of indocyanine green (ICG) fluorescence imaging for SLN mapping versus the standard-of-care 99mTc in the SLN procedure for breast cancer patients.

The impact of self-quarantining on diabetes self-management and distress during the coronavirus outbreak

The current study aims to assess the impact of self-quarantine on glycemic control. In addition, this study describes diabetes self-management, well-being and distress in Dutch patients with type 1 and type 2 diabetes, during a nationwide period of…

A Phase 3 open-label, multicenter study of the safety, efficacy, and pharmacokinetics of intravenous recombinant coagulation Factor VIII Fc-von Willebrand Factor-XTEN fusion protein (rFVIIIFc-VWF-XTEN; BIVV001) in previously treated pediatric patients <12 years of age with severe hemophilia A

To evaluate the safety of BIVV001 in previously treated pediatric subjects with hemophilia A.

Aortic Dynamics after Endovascular Aorta Repair

Gaining information on the dynamics and shape of the stent graft and stented target vessels, and how these change over time will improve our understanding about the fixation and/or sealing of the stent graft, which may help in stent graft selection…

Preventing Relapse After Successful Electroconvulsive therapy (ECT) for Depression: A randomized controlled trial on lithium as add-on to personalized maintenance ECT

Although electroconvulsive therapy (ECT) is an effective treatment for depression, preventing relapse after successful ECT remains a major challenge. In the PRASED-study we evaluate the effectiveness of three strategies to reduce relapse: an…

Eating behaviors of Women with an Eating Disorder and Autism Spectrum Disorder

The goal of this study is to gain insight into the eating behaviors of women with an eating disorder (ED) and comorbid autism spectrum disorder (ASD). By comparing this group to two other groups (women with an ED but without ASD and women with an…

Physiological responses to discomfort induced by the use of technological rehabilitation devices in children

The primary goal of this research project is to study physiological responses of typically developing (TD) children and children with CP (only if the results of TD children are promising) to discomfort induced by the use of technological devices…

SmartCheck- Scoring Meets the ARt of Teamwork

Validate the presence and correlation of intraoperative modifiable risk factors for colorectal seam leaks.