205 results
To assess the correlation between the presence of GIP in urine/ faeces and symptoms after a single dose gluten provocation (mimicking the daily risk of gluten ingestion) in patients with coeliac disease adhering to a strict gluten-free diet.
To assess whether nutritional status can affect the outcome of spatial cognition training in the brain.
To study the efficacy of danazol in patients with pulmonary fibrosis, and to investigate what factors are associated with effective treatment.
The primary objective of this study is to analyse the microenvironment of the tumour, (sentinel) lymph nodes (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients with vulvar carcinoma. The…
The primary objective for this trial is to assess the local cancer control achieved with FLA in patients with localized low to intermediate risk prostate cancer (Gleason 3+3, 3+4 or Gleason 4+3).Secondary objectives are to determine effectiveness of…
The primary objective of this study is to analyse the microenvironment of the primary tumour and sentinel and non-sentinel lymph node(s) (i.e. various T-cell populations, antigen presenting cells and myeloid-derived suppressor cells) in patients…
To establish a healthy control group for microcirculatory parameters for current and future studies on the paediatric microcirculation.
The primary objective is to identify which coagulation factors are associated with unsuccessful reversal of VKA activity. Secondary objectives include the assessment of the number of patients reaching normalized INR (i.e. <1.8) and the number…
The main aim of this study is to investigate if patients that received an ankle arthrodesis, have arthritis in the adjacent joints (subtalar joint and talonavicular joint). Furthermore, we would like to study (1) the amount of increase of arthritis…
To study the interaction between normal T lymphocytes and Hodgkin tumor cells in an in vitro model.
To assess the efficacy of two weeks eucaloric ketogenic diet on GH and IGF-I levels in acromegaly patients.
To investigate if healthy subjects have US-detected features of *inflammation' in order to develop an age-matched homogenous definition of normal variants of wrist, thumb base, metacarpal phalangeal, interphalangeal and metatarsal phalangeal…
Primary Objective: Our overall aim is to improve selection of patients for epilepsy surgery and predict surgical candidacy with use of genetic test results as a biomarker. The specific objectivesare:Cohort I1. Apply genetic testing for epilepsy gene…
• To determine the profile of CNS effects at several time points after 2 mg and 4 mg biperiden in comparison to placebo in healthy elderly subjects.• To investigate the safety and tolerability of biperiden in healthy elderly subjects.• To determine…
The general objective of this study protocol is to add another follow-up measurement, round 7, to the Doetinchem cohort study, 5 years after round 6, and 30 years after round 1 This contributes to an infrastructure of data to tackle research…
Prognostic models and biomarkers in patients with acute decompensated heart failure admitted to ward
Since the ELAN-HF score has only been externally validated in one cohort, the primary objective of this study is to perform an external validation of the ELAN-HF score in a cohort of patients admitted with ADHF at the Catharina Hospital. A second…
Primary objective1) To assess and compare overall QOL during each subsequent line and type of therapy.Secondary objectives:2) To assess and compare therapy satisfaction / decision regret during each subsequent line and type of therapy.3) To assess…
Identify molecular differences in carcinogenesis of LSCC between younger and elderly patients through an integrated proteogenomic analysis of laryngeal tissue biopsies that could optimize personalized treatment of elderly patients in particular.
The main objective is to examine determinants of physical behaviour in patients with SAH (primary in patients with A-SAH and secondary in patients with PM-SAH). Secondary, preferences of patients for therapy to reduce fatigue will be explored in…
This study is a PMCF study to fulfill the post-market surveillance obligations according to Medical Device Directive and MEDDEV 2.12-2. The data collected from this study will serve the purpose of confirming safety and performance of the G7…