1848 results
Primary: To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using BOLD response fMRI imaging.Secondary: 1. To find out which areas in the brain play a part in the…
The relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients.
The primary objective of this study is to examine the relationship between sleep disorders and (reactive) aggression in forensic psychiatric patients in the Forensic Psychiatric Center Dr. S. van Mesdag in Groningen. In addition to this,…
In this study we aim to validate changes in the pulse pressure after controlled volume loss during blood donation in spontaneously breathing subjects. This validation will contribute to the development of a standardized manner in which the Nexfin…
The main objective is to study precision control of trunk posture and associated muscle recruitment in LBP patients and healthy controls during trunk positioning tasks in which postural control is challenged, by increased dead space breathing, by…
To evaluate the blood pressure within the first year of life we will perform a prospective longitudinal study in all newborn patients with the classical form of CAH. To analyze the urinary steroid profile in CAH patients and healthy controls during…
The primary objective of this clinical controlled trial is to define the overall effect of adenocorticotropic hormone on coagulation parameters in patients with primary adrenal insufficiency (as diagnosed by their physician by previous short ACTH…
The first aim is to identify possible mechanisms which cause nocturnal reflux in obese subjects. Secondary aims are to identify the role of weight reduction on reflux parameters and to identify the relation between anthropometric parameters (BMI and…
The aim of this study is to confirm previous findings and examine the functionality of the creatine transporter in RTT girls, at which mutation analysis of the SLC6A8 gene (as a possible cause of an altered functionality of the creatine transporter…
1. To investigate the associations between DSM-IV personality disorder and attachment style. 2. To investigate whether attachment related anxiety and avoidance, as more fundamental personality features than the DSM-IV personality classification,…
Evaluate the prevalence, consistency, and genotype distribution of human papillomavirus (HPV) in semen and to examine the exact localization of HPV (i.e., in the seminal fluid and/or on the membrane or cytoplasm of the sperm cell).Evaluate the…
2.1 Primary Objective• Evaluation of the levels of thrombophilic factors in the blood of HIV-infected patients before starting with cART and the changes of these levels when on cART for the time of one year. 2.2 Secondary Objective• Evaluation of…
To evaluate the predictive value of microcirculatory perfusion for the incidence of Extracorporeal Membrane Oxygenation (ECMO) dependency and consequently survival. To evaluate the effects of vasopressor drugs and iNO on microcirculatory perfusion.
To observe the possible relationship between central, conventional hemodynamic parameters with relatively new peripheral, regional perfusion parameters in two versions of a model with controlled vasocontriction (cooling) - vasodilation (heating)
Hypothetically, in patients with PBC or PSC the FGF-19 production or -response could be altered. The goal of this research is to study the FGF19 production after a standardized oral fat challenge and the effect of this FGF19 production on bile acid…
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
To find out the fate of aneuploid blastomeres
The primary aim of this study is to identify the muscles that are most critical to the abnormal standing posture, standing balance and gait in FSHD patients and to elucidate the most important mechanisms of falls. The ultimate goals are (1) to…
Key hypothesis of the investigation is that Parkinson*s disease is characterized by deficient entrainment of slow brain oscillations. Our previous work already provides preliminary support for this hypothesis. In order to evaluate to what extent…
2.1 Primary ObjectiveTo determine the effect of endothelial dependent and independent vasodilators on endothelial shear stress in humans. 2.2 Secondary ObjectiveTo determine the association between endothelial shear stress and endothelial function…
Primary: To investigate plasma AC profiles of lean and obese subjects in relation to body composition, BMI, insulin sensitivity and energy expenditure.Secondary: To determine if plasma ACs reflect adipose (subcutaneous/visceral) tissue, liver or…