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Open-Label, Multi-Center, Randomized Study of Anti-CCR4 Monoclonal Antibody KW 0761 (mogamulizumab) Versus Vorinostat in Subjects with Previously Treated Cutaneous T-Cell Lymphoma (CTCL)

The main purpose of this study is to determine if KW-0761, an investigational drug will work against cutaneous T-cell lymphoma (CTCL) that has failed to respond to other treatments, and to evaluate its side effects. An investigational drug is one…

The clinical prognostic value of the carotid artery reactivity test in patients with peripheral artery disease

To examine the 1- and 3-year prognostic value of the CAR-test in patients with peripheral artery disease regarding the occurrence of vascular complications and the progression of PAD

Climb Every Mountain

To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.

A randomised phase III trial comparing a strategy based on molecular analysis to the empiric strategy in patients with carcinoma of an unknown primary;A la carte CUP treatment using the CancerTYPE ID test

Determine wether or not a strategy based on molecular analysis is effective in improving the PFS

Neural mechanisms and brain structures underlying individual differences in acquisition of vocabulary and grammar of an artificial language. A neurolinguistic study of language aptitude.

Primary Objective: The main objective is to gain insight into the functional and structural neural correlates of success in foreign language learning. To this end, fMRI and DTI data will be acquired together with behavioral responses from healthy…

A short CBT intervention for sexual rehabilitation among women receiving radiotherapy with gynecological cancer: A pilot study.

To investigate whether a short CBT intervention for sexual rehabilitation is feasible for patients (and their partners) and professionals. The available literature underscores the importance of sexual problems after pelvic RT and the need to develop…

The effectiveness of Mindfulness Based Compassionate Living (MBCL) in adults with recurrent depression.

To investigate the effectiveness of Mindfulness Based Compassionate Living (MBCL) in recurrent depressive patients.

Unraveling the molecular and Cellular muscular mechanisms associated with Aging in rotator cuff Tears of the Shoulder

Identification of the molecular and cellular muscular mechanisms associated with aging in rotator cuff muscles with radiological quantification and clinical data.

The use of Prevena Incision Management System on clean closed sternal midline incisions in subjects at high risk for surgical site occurrences.

The objective of the study is to assess the performance of topical negative pressure therapy application with Prevena* Incision Management System (IMS) versus standard conventional wound therapy (SCWT) on closed median sternal incisions in patients…

BIOTRONIK - Safety and Clinical Performance of the Drug Eluting Absorbable Metal Scaffold (DREAMS 2nd Generation) in the Treatment of Subjects with de Novo Lesions in Native Coronary Arteries: BIOSOLVE-II

Assessment of safety and clinical performance of the DREAMS 2nd Generation in de novo coronary artery lesions.

A post market clinical follow-up study with the Optimys Stem, with initial RSA analysis

To document the initial stabilty of the Optimys stem with radiostereometric analysis in the first 30 patients, and to perform a clinical follow up of at least 150 patient treated with this implant to document the outcome.

A RANDOMIZED TRIAL COMPARING RADICAL HYSTERECTOMY AND PELVIC
NODE DISSECTION VS SIMPLE HYSTERECTOMY AND PELVIC NODE DISSECTION
IN PATIENTS WITH LOW RISK EARLY STAGE CERVICAL CANCER

Primary objective:To evaluate whether treatment with simple hysterectomy and pelvic node dissection is non-inferior to treatment with radical hysterectomy and pelvic node dissection in terms of pelvic relapse-free survival.Secondary objectives:To…