30 results
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.
We hypothesize that the new MRI protocol will be sensitive enough to detect a diagnostic change of >= 50% change from the normal shaped trachea. The primary objective of this study is to determine sensitivity, and specificity, of our MRI…
To examine the presence of structural and functional brain changes in glaucoma patients. Specifically, we are interested in the presence of glaucomatous functional brain changes that are beyond those that can be explained on the basis of propagated…
This study aims to establish the diagnostic accuracy of functional MRI techniques and MET-PET individually and combined in treatment evaluation of glioblastoma.
To evaluate the safety and performance of the MobiusHD system in subjects with resistant hypertension. Substudy HF:As above, and obtain an initial understanding of the efficacy of the MobiusHD System on cardiac performance and functional status in…
The primary objective is to determine whether adjuvant treatment with natural dendritic cell (nDC) vaccination, after complete radical lymph node dissection or sentinel node procedure in stage IIIB and IIIC melanoma patients, improves recurrence-…
The aim is to investigate the differences in pathogenesis of nonbullous and bullous pemphigoid by comparing gene expression, and the presence of activated and apoptotic eosinophils and IL-31 expression in skin, blood and blister fluid of both…
The proposed study aims to examine the antidepressant efficacy of oral S-ketamine augmentation in patients with TRD treated with regular antidepressants in a double-blind randomised controlled trial. Secondary questions involve the effects of oral S…
Primary Objective: to investigate whether half-dose PDT treatment leads to a higher percentage of cCSC patients with SRF on OCT at baseline, achieving an absence of this SRF on OCT as compared to eplerenone treatment.Secondary Objectives: to…
To evaluate whether YCF with added scGOS/lcFOS and n-3 LCPFUAs can decrease the number of upper respiratory tract infections compared to cow*s milk in children aged 12-36 months with recurrent upper respiratory tract infections.
The purpose of this study is to evaluate the effects of the addition of daratumumab to pomalidomide and dexamethasone in subjects with relapsed or refractory MM.1. Primary objectiveThe primary objective of this study is to compare PFS between…
Primary objective: To evaluate the performance of the SCP procedure in treatment of bone marrow lesion(s) (BML(s)).Secondary objective:Secondary objectives include documenting clinical outcomes such as pain, function of daily living, function of…
The primary objective is to assess whether combination treatment BLM+RTX will lead to reduced treatment failure and the improvement of pivotal, SLE-specific autoimmune phenomena compared SLE patients treated with standard of care.
1 - To determine the feasibility of MRD detection using next generation sequencing (NGS) on circulating tumor DNA (ctDNA) from PTLD patients using a gene panel previously used in diffuse large B-cell lymphoma (DLBCL) 2 - To explore the mutational…
Primary research questions:(1) What is the rate of persistent DSM-5 moderate to severe SUD from adolescence to young adulthood among youth in addiction treatment?(2) What is the prognostic value of a general population-based set of predictors of…
Primary objective:1. To study the relation between muscle FF and two major clinical endpoints in different phases of the disease in non-ambulant DMD patients. Secondary objectives:2. To explore the use of Microsoft Kinect and Leap Motion in relation…
• AIS is a chronic condition of the back. Once the curvature shows progression and exceeds a Cobb angle of about 20 degrees, chances are small that this curvature will disappear spontaneously.2 There is little epidemiological data of the Netherlands…
Primary Objective: To optimize the current DBS-treatment of advanced PD. For the primary objective the following research questions will be answered: By performing STN DBS under general anesthesia, will there be a significant reduction in cognitive…