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Stress system dynamics in childhood trauma-related depression

The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…

Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment ofStargardt Disease in Adolescent Subjects

This study has been transitioned to CTIS with ID 2024-513483-26-00 check the CTIS register for the current data. To assesses the efficacy of Tinlarebant in slowing the rate of growth of atrophic lesion(s) in adolescent subjects with STGD1.

Preoperative sodium glucose cotransporter 2 inhibitors for prevention of postoperative acute kidney injury in cardiac surgery patients - a randomized, placebo-controlled, multi-centre, phase IV clinical trial

This study has been transitioned to CTIS with ID 2024-515260-31-00 check the CTIS register for the current data. To investigate the potential of preoperative initiation and perioperative continuation until day 2 after surgery of the SGLT2 inhibitor…

DEnosumab for the treatment of FIbrous Dysplasia/McCune-Albright Syndrome in adults (DeFiD): a randomized double-blind placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-511090-30-00 check the CTIS register for the current data. To investigate whether 3 monthly Dmab will improve the clinical, radiological and biochemical manifestations of FD bone lesions.

Evaluating the effect of Agaricus bisporus powder intake on the vaccination response to an influenza vaccine

The primary objective of this study is to demonstrate the effect of consuming daily 5 grams of Agaricus bisporus powder (10 capsules) on the vaccination response to an influenza vaccine in men and women aged 60 years or older during the influenza…

Stress-induced immune reprogramming in cardiovascular disease (STRESS-CVD)

To investigate whether high perceived stress is associated with inflammatory reprogramming of innate immune cells and their bone marrow progenitors, and with increased arterial wall inflammation, in subjects with an increased CVD risk.

Blood donation for experimental in vitro research

Sample collection for in vitro research

Peroperative Administration of Tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce hemorrhage rates (PATRY study): a randomized controlled trial

This study has been transitioned to CTIS with ID 2024-513570-22-00 check the CTIS register for the current data. This trial aims to investigate whether peroperative administration of TXA reduces haemorrhage rates in patients who undergo metabolic…

Impella®-Supported PCI in High-Risk Patients with Complex Coronary Artery Disease and
Reduced Left Ventricular Function: The PROTECT IV Trial

The primary objective of the PROTECT IV Trial is to demonstrate the superiority of percutaneous coronary intervention (PCI) performed with Impella® mechanical circulatory support (MCS; Impella CP®, Impella CP® with SmartAssist® or Impella 2.5®…

Nutritional intake, nutritional status and physical activity level in people who have undergone a major dysvascular lower limb amputation

The primary objective of this study is to determine the nutritional intake, nutritional status, and physical activity level at various moments post-lower limb amputation (i.e., during hospital admission for amputation, at 5 weeks post-amputation, at…

Prospective randomized multi-center controlled clinical investigation comparing PFO outcomes of the Occlutech Flex II PFO Occluder to standard of care PFO occlusion.

The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…

Study on PhArmacokiNetics of first liNe Antiretrovirals in healthy Breastfeeding volunteers
(PANNA-B PK)

This study has been transitioned to CTIS with ID 2023-510232-36-00 check the CTIS register for the current data. to determine the concentration of currently often used ARV (doravirine, raltegravir, bictegravir, tenofovir alafenamide, emtricitabine)…

A Phase 1/2 Randomized, Umbrella Study to Evaluate the Safety and Efficacy of Pembrolizumab Plus Enfortumab Vedotin (EV) in Combination With Investigational Agents Versus Pembrolizumab Plus EV, as First-Line Treatment for Participants With Advanced Urothelial Carcinoma (KEYMAKER-U04): Substudy 04B

This study has been transitioned to CTIS with ID 2023-506385-30-00 check the CTIS register for the current data. Primary Part 1:-To evaluate ORR in participants treated with MK-4280A plus EV (Arm A), MK-7684A plus EV (Arm B), and pembrolizumab plus…

A Multi-Centre Study in Patients Undergoing Total Knee Replacement with Smith+Nephew Porous Total Knee Arthroplasty (TKA) System.

The primary objective is to assess 2-year survivorship of Total Knee Arthroplasty (TKA) procedures performed using the Smith+Nephew (S+N) Porous Knee System. The secondary objective is to generate safety and performance evidence up to 5 years post-…

Sample Stability Elecsys Troponin T hs Gen 6

Primary objectiveThe objective of this study is to demonstrate the 12 month stability of cTnT in native serum, Li-heparin plasma and K2-EDTA plasma samples at -20 ± 5 °C, > 4 hours at 15 to 25 °C, > 24 hours at 2 to 8°C and > 12…

nCLE-guided bronchoscopy for peripheral lung cancer diagnosis: a Randomized Controlled Trial

To evaluate the added value of nCLE-imaging to conventional bronchoscopic peripheral lung lesion analysis on the diagnostic yield.

Comparison of a solid state versus balloon esophageal catheter for estimation of pleural pressure in surgical ICU patients

To evaluate the accuracy of Pes measurement with a solid-state catheter during controlled and assisted ventilation.

ABCD-study Phase 7: follow-up measurements at age 19-20 years*

Objectives of phase 7 of the ABCD-study are:(i) to follow-up on growth trajectories during childhood/adolescence and identify lifestyle and environmental factors that influence thesetrajectories;(ii) to follow-up on cardiometabolic health during…

Efficacy of Pectoral Nerve (PECS II) Block with Liposomal Bupivacaine versus Levobupivacaine for Patients undergoing a Mastectomy: A Prospective Randomized Controlled Trial.

This study has been transitioned to CTIS with ID 2024-515183-30-00 check the CTIS register for the current data. The aim of this prospective randomized, double blind study is to evaluate the analgesic effects of pre-operative PECS II-block with (…

Hemodynamic characterization of the respect and resect approaches in mitral valve repair surgery: a 4D-flow MRI study (RES-P-ECT 4D trial)

The aim of this study is to investigate potential differences in blood flow patterns, wall shear stress and energy loss in patients after mitral valve repair with the resect and respect approach.