169 results
This study aims to elucidate the relationship between subjective controllability and dopamine in PD patients. We hypothesize that lower levels of dopamine will be related to lower estimations of controllability. Using fMRI, we will investigate the…
The overall aim is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation. The primary objective is to investigate the changes in regional lung stress…
The primary objective of the CRT-DRIVE study is to test the hypothesis that at least 75% of patients undergoing a CRT implantation guided by non-invasive electrical and venous anatomy assessment (XSPLINE technology) will show a reduction of left…
To investigate if resection with a margin, that is significantly beyond the radiological contrast enhancement, improves overall survival in selected patients with glioblastoma.
To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment.
To assess the effectiveness of EMDR in RA patients with persistent pain despite inflammation being under control.
The overall aim of this project is to unravel the role of IFN-I in ILD in the known/classified SADs and in ILD with autoimmune features but without a specific SAD diagnosis (IPAF), with as ultimate goal better treatment. Since 13-40% of ILD patients…
The objective of the SEAL Early Feasibility Study (STUDY) is to provide proof of concept and initialclinical safety data for the Aortoseal Endostapling System for the fixation and seal of abdominal aorticaneurysms (AAA) endovascular grafts to the…
Primary Objective:Our overall aim is to develop an easy-to-use, and interpretive method for the early detection of valvular heart disease and thoracic aortic aneurysm based on arterial blood pressure waveforms, collected non-invasively. Therefore,…
The aim of this study is to characterize the immune system and its changes over time. We aim to identify the factors that influence the kinetics of immune system aging, to describe potential aging endotypes in different individuals, and correlate…
The overarching objective of this master protocol is to study the risk factors (personal, clinical and lifestyle factors) for-, and consequences of- , changes of nutritional status (both over- and undernutrition) in children with cancer. Based on…
Our primary objective is to investigate whether EMDR and Imagery Rescripting are effective for individual patients who experience intrusions: patients with PTSD, patients with depression, and patients with PTSD and a comorbid depression. To this end…
Primary Objective: To study the early diagnostic performance of specific gene signatures for differentiation of patients having postoperative infection (A1) or sepsis (A2) from non-infected patients having postoperative SIRS (B1) and non-infected…
The primary objective of this feasibility study is to demonstrate the initial safety and effectiveness of the CellFX® nsPFA* Cardiac Clamp in performing a box lesion around the 4 pulmonary veins as an isolated procedure or as a part of a more…
To investigate the effectiveness of an anti-inflammatory diet in reducing pain symptoms among patients with endometriosis and to explore whether the addition of CBT enhances this pain-reducing effect apart from the effect of CBT alone. The secondary…
Our main goal is to clarify the behavioural and neurophysiological effects of short-term TUS on deep brain circuits in humans. We will compare the effects of Amygdala-TUS, dACC-TUS and sham-TUS to one-another using a behavioural task and fMRI. Our…
Primary Objectives• To evaluate prognostic factors of disease progression in subjects with Stargardt disease secondary to mutation in the ABCA4 gene • To further characterize the STGD1 patient population for future interventional clinical studies
The primary objective of the current pilot study will be to assess the feasibility of participant selection methods to identify individuals with cam morphology free of hip OA.Secondary objectives includea) the evaluation of the willingness of…
The objectives of EUROASPIRE VI survey of CVD prevention and diabetes are:1. To determine in patients with established CHD (CHD = acute myocardial infarction (AMI) and acute ischaemia (unstable angina) and patients following revascularisation by a…
To compare the plasma concentration versus time profiles and postprandial bioavailability of DHA and EPA after a nutritionally relevant oral dose of 1.1 gram (expressed as DHA + EPA) administered as either CCx gelatin-based soft chews (emulsified)…