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Comparison of a single dose fibrinogen with placebo and the number of blood transfusions after ascending aorta surgery (FIBTEG study)

The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic blood transfusions,…

EUROPEAN ECLIPSTM SAFETY, FEASIBILITY AND EFFICACY STUDY (EESIS) PROTOCOL
A multi-center post marketing study evaluating the safety, technical feasibility, and efficacy of the eCLIPsTM Family of Products for the treatment of bifurcation intracranial aneurysms.

To provide preliminary technical feasibility, safety and efficacy data foreCLIPs Family of products.

*CompLement C5 Antibodies for decreasing brain injury after aneurysmal Subarachnoid Hemorrhage: safety and proof-of-concept*

This study aims to investigate the biological efficacy and safety of eculizumab in patients with aneurysmal SAH.

Subarachnoid Bleeding Prognosis by Acutely RupTured Aneurysm Study

Objective: The aim of this comparative study is to identify the highest value-based practice for ruptured intracranial aneurysm patients in the short-, medium-, and long term by prospective registration.

Aortic Dynamics after Endovascular Aorta Repair

Gaining information on the dynamics and shape of the stent graft and stented target vessels, and how these change over time will improve our understanding about the fixation and/or sealing of the stent graft, which may help in stent graft selection…

Unruptured Cerebral Aneurysm: prediction of evolution: a prospective multi-centre study

Our primary aim is to evaluate in clinical practice the predictive value of unruptured intracranial aneurysm wall enhancement for aneurysm growth. It will allow to set up a secure, efficient and personalized follow-up.

*Quantification of wall pulsations in intracranial aneurysms with 4D CTA: a pilot study. *

Detecting and quantifying the cardiac cycle-related pulsatility of the intracranial aneurysm wall with 4D CTA. Besides, the pulsating belbs will be differentiated from noise-induced pulsations.

Prospective Randomised Open-label Trial to Evaluate risk faCTor management in patients with Unruptured intracranial aneurysms (PROTECT-U)

This study has been transitioned to CTIS with ID 2024-517236-22-00 check the CTIS register for the current data. The main purpose of this study is to assess the hypothesis that a strategy with ASA 100mg/day and intensive blood pressure treatment (…

Flow diverter (surpass) for unruptured intracranial aneurysms: A prospective single-center study in 37 patients - long-term follow-up

The primary objective is to evaluate long-term reperfusion rate, neurological outcome and quality of life in patients with unruptured intracranial aneurysm treated with the Surpass Flow Diverter (Surpass; Stryker Neurovascular, Fremont, CA).

Deferoxamine in Aneurysmal Subarachnoid Hemorrhage trial

This study has been transitioned to CTIS with ID 2024-514615-10-01 check the CTIS register for the current data. This study investigates the effectivity and the safety of deferoxamine use in patients with aneurysma subarachnoidhemorrhage.

Exploratory study regarding the use of Neurophysiological Monitoring Techniques to Detect Spinal Cord Ischemia in Patients after Thoracoabdominal Aortic Aneurysm Repair

The purpose of this study is to explore the usefulness of various neurophysiological tests regarding accuracy and feasibility for the detection of spinal cord ischemia. In particular, to find a diagnostic test which is acceptable for the…

Feasibility of ultrasound particle image velocimetry to quantify flow in the abdominal aorta before and after endovascular aneurysm repair

The aim of this study is to determine the feasibility of ultrafast contrast-enhanced ultrasound particle image velocimetry (echoPIV) measurements to quantify spatiotemporal blood flow velocity profiles in the abdominal aorta of AAA patients before…

EndurAnt Stent Graft system vs ExcluDer endoprothesis: a global, prospectiVe, rANdomized Clinical trial in sac rEgression (ADVANCE Study)

The purpose of this study is to generate clinical evidence related to key performance outcomes of Endurant II/IIs Stent Graft System versus Gore Excluder/Excluder Conformable AAA Endoprosthesis in subjects with AAA.

Metformin for AAA Growth Inhibition: A randomized controlled trial

This study has been transitioned to CTIS with ID 2024-517387-37-00 check the CTIS register for the current data. The proposed multi-center population-based open-label randomized controlled trial with blinded outcome assessment will examine if…

Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and asperin, versus IVIG and asperin for prevention of coronary artery aneurysm (CAA) in Kawasaki disease (KD)

The overarching goal is to optimise the treatment of KD in children/adolescents across Europe.KD-CAAP will test the hypothesis that adding immediate adjunctive corticosteroid treatment to IVIGand aspirin will reduce CAA rates in unselected KD…

A preoperative program to promote peri- and postoperative health in patients undergoing thoracic aortic surgery: a randomized controlled trial.

To compare the effects of a preoperative PA program in addition to usual care versus usual care only on the change in SB from baseline (T0) to the end of the preoperative (intervention) period (T1) in patients with TAD.

A 12 month, open label, parallel-cohort study to evaluate the efficacy, safety and tolerability of canakinumab in children with Kawasaki disease

The objective of this study is:1. To evaluate the efficacy, safety and the tolerance of Canakinumab in 'IVIG-resistent' patients (cohort 1) and 'IVIG-naive' patients (cohort 2) with Kawasaki disease.2. To evaluate the incidence…

The *Long-term Evaluation of elective neurovascular imAge-Guided and neUrosurgical trEatments (LEAGUE-neuro)* study

To set up a prospective cohort that facilitates evaluation of elective neurovascular treatments and that will serve as a multi-trial platform.

Subarachnoid haemorrhage (SAH): brain damage, cognitive and behavioral functioning as predictors of recovery.

The research project focuses on identifying early predictors (brain damage, cognition and behavior) for recovery after a SAH. The research also focuses on using advanced neuro-imaging for better mapping of (indicators of) brain damage after a SAH,…

Tonometry(1) and duplex ultrasound(2) to predict cardiovascular events in to be treated patients with an abdominal aortic aneurysm

The aim of this prospective 2-year follow-up study is to investigate the predictive capacity of the CAR-test for development of cardiovascular events after elective AAA repair in comparison to the SMART risk score. Secondary objectives are to…