469 results
Identification of genetic and biochemical riskfactors for CHD in patiente with chestpain. The identification of (genetic and biochemical) markers that determine the efficacy of a medical or invasive therapy in these patients.
The aim is to evaluate the effectivity of training in mindfulness with patient who underwent a PCI-procedure on different variables: (i) psychological wellbeing (mood, anxiety, depression and quality of life), (ii) clinical relevant physiological…
In the current study we want to obtain fundamental insight in the role of insulin-mediated glycocalyx modulation as well as the effect of FFAs on this mechanism. We propose that increased levels of FFA degrade the glycocalyx and result in an…
The objective of the proposed study is to evaluate the efficacy on risk factor management and toevaluate cost-effectiveness of an internet-based risk factor management program for patients at highcardiovascular risk.The research questions are…
To confirm the performance and long term safety of MisagoPeripheral Self-Expanding Stent System for the treatment ofoccluded or stenotic Superficial Femoral or Popliteal arteries in thedaily practice
To demonstrate the efficacy of a PTFE covered stent-graft in the prevention of outflow re-stenosis in loop fistula in a prospective trial.
1) to assess the distensibility of carotid arteries and to relate the distensibility to the presence of atherosclerosis.2) to assess the image quality of motion free reconstructed images with ECG-gated CT scans.
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.
1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
Primary research questionDo obese PCOS women with reduced insulin sensitivity have HDL particles that have impaired anti-oxidative function in comparison with lean controls with normal insulin sensitivity?Secondary research questionDo obese PCOS…
The main goal of the study is evaluation of the effects from renal artery stenosis on intrarenal flow-distribution and tubular function. Assumed and measured effects are alterations of medullary flow, inflammatory markers and overall tubular…
To identify morphological and molecular characterisations of resected carotid plaques. And to determine biomarkers in serum. The emphasis will lie on inflammatory biomarkers such as Cathepsines and matrix metalloproteinases. Also it will be examined…
To study the impact of treating potentially modifiable vascular risk factors in HIV-1 infected patients by a nurse-led vascular intervention program
We hypothesise that EC dysfunction is present in SLE and WG patients compared to controls. In summary, our hypothesis leads to the following questions:1. Is EC dysfunction, measured by SAE, present in SLE patients?2. Is EC dysfunction related to EC…
Primary objective:- to identify risk factors for cardiovascular disease following treatment for testicular cancerSecondary objective:- to investigate genetic polymorphisms that are potentially involved in the development of treatment-related…
Prevalence of cardiovascular disease and their risk factors in patients with ankylosing spondylitis.
This research must answer the following questions: (1) what is the prevalence of CVD in AS patients?(2) what is the incidence of CVD in patients with AS? (3) which risk factors contribute to the development of CVD in AS? (4) to which extent AS…
The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…
The aim of the study is to assess the possible additive value of the AGE reader measurement in a group of hospital-controlled (high-risk) persons with type 2 DM.
1. To adjust and validate our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemic postconditioning.To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia…
To study whether ticagrelor, added to acetylsalicylic acid, modulates the inflammatory response to the administration of lipopolysaccharide (LPS) in humans in vivo.