55 results
1 To evaluate the feasibility to measure cortisol levels in hair in healthy children and children with asthma who use inhaled corticosteroids2 To evaluate differences in cortisol levels in hair in healthy children and children with asthma who use…
To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.
The objective of the study is to determine whether it is necessary to take the blood pressure lowering medication (β-blocker, ACE-inhibitors or diuretics) of a patient into account prior to blood sampling for pheochromocytoma diagnostics. Therefore…
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
We hypothesize that cardiovascular risk factors may already be present during childhood in CAH patients. Therefore, we will perform a cross-sectional study in CAH patients aged 1-16 years evaluating blood pressure, lipid profile, insulin sensitivity…
Evaluate the effect of topical steroids on salivary cortisol levels, and assess the correlation between salivary cortisol levels, symptoms of asthma, and lungfunction in children with asthma and/or rhinitis
With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…
Assess the prevalence of the metabolic syndrome and quality of life in patients with Addison*s disease treated with low dose GRT. Study the relation between GRT, QoL and glucocorticoid receptor polymorphisms
To investigate the correlation between androstenedion in saliva and serum in all patients that have a request for androstenedion in serum.To collect age related reference ranges for healthy children on three different time points.
Exploring the incidence of fatigue after sarcoidosis, its severity and nature. Next we will try to associate fatigue with capacity to produce pro- and anti-inflammatory cytokines.Our secondary objective is testing the activity of the HPA-axis, the…
To evaluate if a standardized running test will elicit an increase in salivary cortisol levels in healthy prepubertal children
1. Study of the incidence of TART in male CAH children in a multicentre setting 2. Detection of predisposing factors for tumour growth. 3. Evaluating of gonadal function in male CAH children with TART
In this pilot study we want to determine if a standardized cyclic ergometer test result sin a measurable and reproducible cortisol response.
To investigate cortisol and ACTH rhythm (frequency, amplitude and regularity of cortisol and ACTH secretory pulses) in patients with SCS and bilateral adrenal involvement.
To study the variability of the lateralisation of the aldosterone/cortisol ratio*s when 3 instead of 1 sample is obtained and to study whether instantaneous measurement of cortisol during the procedure will prove to be advantageous.
The aim of the present study is to assess the necessity of dietary restrictions before sampling for the biochemical diagnosis of pheochromocytoma. Therefore, the short-term influence of a catecholamine-rich diet on plasma free and total metanephrine…
In this study we want to investigate long-term follow-up of patients with PA. The outcome will be analyzed based on whether a decision to treat was guided by CT/MRI or AVS or both.
Primary objective:a. How often do inhalation or nasal corticosteroids lead to suppression of the HPA- axis in HIV-treated patients? Secondary objectives:b. Are other variables associated with the HPA-axis suppression? c. Are cortisol measurements in…
The primary objective is to determine which of two commonly used drugs for preoperative management provides the best intraoperative hemodynamic control in patients undergoing resection of a PCC. Secondary Objective(s): o to identify other…
To detect differences between ACC patients and controls without ACC, and between the diseased and healthy adrenal gland of ACC patients, in microRNA (miRNA), circulating cell-free tumor DNA (ctDNA), circulating tumor cells (CTCs), and steroid…