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Plaque stabilization and restoration of vascular function by bioresorbable vascular scaffold in acute coronary syndrome prone patients

To assess if treatment of an intermediate vulnerable coronary lesion in symptomatic patients using a BVS is feasible, results in a more stable plaque, increases vessel luminal area, preserves or improves vasomotion and is not associated with…

A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events with Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients with History of Myocardial Infarction

The current study is being conducted to determine whether long-term dual-antiplatelet therapy with ticagrelor in combination with ASA (recommended daily dose 75-100 mg) is beneficial in patients with history of MI (1-3 years ago) and additional risk…

The effects of on the rheologic properties and oxygen transport capacity of red blood cells processed by 3 different types of cell savers, and its effects on microcirculatory blood flow and tissue oxygenation in vivo

The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…

The effect of exercise on the prevention of endothelial ischemia-reperfusion injury

To examine the impact of an exercise bout on the ability to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the potential difference in efficacy to prevent ischaemia…

The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery.

Should low-dose aspirin be continued up until the day of CABG or OPCAB surgery?Should TxA be used for all at-risk CABG or OPCAB surgery?

Epidural anesthesia for OPCAB, a randomized comparison between general anesthesia alone or general anesthesia combined with high thoracic epidural anesthesia for off pump CABG

In the present study we will determine the effect of sympathetic blockade by TEA on major outcome parameters after off-pump CABG.

A RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE EFFICACY AND SAFETY OF THE REG1 ANTICOAGULATION SYSTEM COMPARED TO BIVALIRUDIN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Primary To determine the efficacy of REG1 compared to bivalirudin in patients with coronary artery disease (CAD) undergoing Percutaneous Coronary Intervention (PCI) for preventing the composite of death, nonfatal myocardial infarction, nonfatal…

Implementation of Cardiovascular Risk management for patients with Rheumatoïd Arthritis (I-CaRe)

The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…

Early treatment of Atrial Fibrillation for Stroke Prevention Trial (EAST)

To test whether an early, comprehensive, rhythm control therapy can prevent adverse cardiovascular outcomes in patients with recent-onset atrial fibrillation (AF) compared to usual care.

Comparison of a single dose fibrinogen with placebo and the number of blood transfusions after ascending aorta surgery (FIBTEG study)

The purpose of this study is to answer the following question: Leads a primary coagulation corrected with a single dose of fibrinogen concentrate after ascending aorta-arc reconstruction to a decrease in the number of allogenic blood transfusions,…

Vitamin K antagonist (VKA) therapy versus New Oral Anticoagulants (NOACs) therapy in patients with currently well controlled VKA therapy for non-valvular atrial fibrillation: a pilot study

Objectives:To collect data on effect size for, and determine the feasibility of, a full scale multicentre RCT(Randomized Controlled Trial) that1. compares the efficacy and safety of NOACs with VKA treatment according to Dutchstandards, in VKA-…

Randomized clinical trial for an extended cardiac rehabilitation program using telemonitoring

To assess whether an extension of the cardiac rehabilitation program with telemonitoring guidance results in better long term effects on physical and mental outcomes than a regular follow-up period after traditional cardiac rehabilitation.

The impact of heart failure on exercise-induced cardiac fatigue: an explorative study

Primary objective: To compare the impact of a single day of prolonged walking exercise on cardiac function and biomarker responses between heart failure patients and their age- and sex-matched controls.Secondary objective: To compare the impact of 1…

Finding the optimal treatment of severe panic symptoms in patients presenting at the emergency department with non-cardiac chest pain or palpitations. A cognitive behavioural therapy based intervention versus an information sheet. A randomized controlled trial.

The objective of our study is to examine the effectiveness of a cognitive behavioural therapy based intervention compared to an information leaflet on anxiety symptoms after one month, in patients presenting at the emergency unit with non-cardiac…

Explorative study on the impact of tea ingestion on forearm resistance artery endothelial function

To examine the acute impact of tea ingestion on forearm resistance artery endothelial function in middle-aged subjects

Effects of polyphenol supplementation on inflammation and coronary endothelial function in patients with documented coronary artery disease

Primary Objective: The primary objective is to assess the effects of the oral administration of a daily dose of 1000 mg polyphenol extract for 3 weeks on biochemical markers of leucocyte recruitment in patients with documented CAD. Secondary…

A Prospective, Randomized Evaluation of the TriGuard* HDH Embolic DEFLECTion Device during Transcatheter Aortic Valve Implantation

To assess the safety, efficacy, and performance of the TriGuard HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with patients undergoing unprotected TAVI.

A prospective, single arm feasibility pilot study to evaluate the safety and performance of the TriGuard*-HDH Embolic Deflection Device in patients undergoing Transcatheter Aortic Valve Replacement (TAVR)

To demonstrate the safety and performance of the Embolic Deflection Device (TriGuard*HDH) in patients undergoing Transcatheter Aortic Valve Replacement (TAVI).

Cost-effectiveness of a lifestyle intervention on health and sustainable employability among workers of 40 years and older with high physical work demands: a randomized controlled trial

- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.

After the Health Check in vulnerable groups: an individually tailored self regulation intervention led by Community Health Workers.

The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…