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Perioperative Transfusion Study (PETS): does a liberal transfusion protocol improve outcome in high-risk cardiovascular patients undergoing non-cardiac surgery?

The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…

Follow up MISSION!: Optimization of chronic care for patients with acute myocardial infarction and long term course of cholesterol.

Primary Objective:- To assess lipid levels of STEMI patients over a long course. Secondary Objectives:- To assess the association between poorly controlled cholesterol and (apo) lipoprotein levels for the long term outcome in STEMI patients.- To…

The Lipid-Rich Plaque Study

The Lipid-rich Plaque Study will be performed in patients undergoing IVUS-NIRS imaging (the index procedure) in whom a TVC catheter will be purchased and used for routine clinical indications. The study will test the ability of multi-vessel NIRS…

Double-blinded, randomised, placebo-controlled, multicentre , Phase IIa study to investigate the effect, safety and tolerability of phosphorylcholine human monoclonal antibody (PC-mAb) 3G10 on arterial inflammation, together with safety and tolerability, in subjects with elevated lipoprotein a (Lp[a ])

1. The primary objective is to assess the effects of four 250 mg PC-mAB (also referred to as "3G10") once monthly intravenous injections on monocyte function ex vivo. The secondary objectives are to:1. assess the functional effects of 3G10…

ACS Prototype for 'post-discharge self-management'- proposition for patients, medical staff and care institution.

To gain qualitative insights into the value of the *ACS post-discharge self-management proposition* for patients, medical staff and care institution. Understand how this prototype is used in practice by patients and staff * Investigate how it…

Red wine polyphenols improve cardiometabolic risk in obese subjects by alleviating
inflammation and microvascular dysfunction

Primary Objective: To study effects of RWPs on insulin sensitivity, glucose tolerance, microvascular function (skin and muscle), insulin-mediated microvascular responsiveness, and blood pressure.Secondary objectives: To study effects of RWPs on…

Modification of risk with MSCT- coronary angiography in high-risk cardiac asymptomatic patients.

To demonstrate whether using MSCT to reclassify individuals who are at high-risk based on traditional risk factors.

The effect of exercise on the prevention of endothelial ischemia-reperfusion injury

To examine the impact of an exercise bout on the ability to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the potential difference in efficacy to prevent ischaemia…

The ATACAS Trial: Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial. A prospective, randomised, double blind, factorial trial testing whether aspirin, tranexamic acid, or both, can reduce mortality and/or major morbidity after elective coronary artery surgery.

Should low-dose aspirin be continued up until the day of CABG or OPCAB surgery?Should TxA be used for all at-risk CABG or OPCAB surgery?

A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial, to Assess the Prevention of Thrombotic Events with Ticagrelor Compared to Placebo on a Background of Acetyl Salicylic Acid (ASA) Therapy in Patients with History of Myocardial Infarction

The current study is being conducted to determine whether long-term dual-antiplatelet therapy with ticagrelor in combination with ASA (recommended daily dose 75-100 mg) is beneficial in patients with history of MI (1-3 years ago) and additional risk…

A RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE EFFICACY AND SAFETY OF THE REG1 ANTICOAGULATION SYSTEM COMPARED TO BIVALIRUDIN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Primary To determine the efficacy of REG1 compared to bivalirudin in patients with coronary artery disease (CAD) undergoing Percutaneous Coronary Intervention (PCI) for preventing the composite of death, nonfatal myocardial infarction, nonfatal…

The effects of on the rheologic properties and oxygen transport capacity of red blood cells processed by 3 different types of cell savers, and its effects on microcirculatory blood flow and tissue oxygenation in vivo

The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…

Epidural anesthesia for OPCAB, a randomized comparison between general anesthesia alone or general anesthesia combined with high thoracic epidural anesthesia for off pump CABG

In the present study we will determine the effect of sympathetic blockade by TEA on major outcome parameters after off-pump CABG.

*Cost-effectiveness study of the HEART score in the management of patients with chest pain presenting in the emergency room*

To quantify the impact of the use of the HEART risk score on patient outcome (major adverse cardiac events(MACE) and quality of life) and on costs in patients with chest pain presenting at the emergency room.

Effects of polyphenol supplementation on inflammation and coronary endothelial function in patients with documented coronary artery disease

Primary Objective: The primary objective is to assess the effects of the oral administration of a daily dose of 1000 mg polyphenol extract for 3 weeks on biochemical markers of leucocyte recruitment in patients with documented CAD. Secondary…

Impact of aging and fitness on ischaemic preconditioning in humans

To examine the impact of age and physical fitness on the ability of ischaemic preconditioning to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the role of Toll-like…

Optimising the effects of exercise in diabetes

We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.

A randomized, double-blind, placebo-controlled, event-driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with elevated hsCRP (CANTOS study, CACZ885M2301)

Primary: to demonstrate the superiority of at least one dose of canakinumab compared to placebo in reducing the risk of recurrent major cardiovascular disease events (cardiovascular death, non-fatal MI and stroke) in a population of clinically…

Stress reduction by respiratory bio feedback training as an additional rehabilitation method after acute myocardinal infarction.

The objective of the study is to investigate if respiratory feedback training as an additional rehabilitation method after acute myocardial infarction might improve quality of live Primary objective: Is quality of live as measured by the "Heart…

Information needs and information seeking behaviour of patients receiving cardiac rehabilitation

The main goal of this study is to investigate information needs and seeking behaviour in patients entering cardiac rehabilitation. Secondary goals are to investigate changes in information needs and seeking behaviour directly after cardiac…