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Peanut protein detection in serum

The primary objective is to set-up a well-defined sandwich ELISA method to measure the levels of Ara h6 in blood after peanut consumption.

Biomarkers of the HIV reservoir

Primary objectivesLongitudinal quantification of the total latent HIV reservoir with determination of the size of the replication competent HIV reservoir and investigate potential biomarkers of the HIV reservoir size and nature.Cross compare the…

DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-

To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.

Dose range finding pilot study for diagnostic patch testing with ME-PPD

Primary Objective: Pilot study to identify the optimal patch test concentration for detecting contact allergy to ME-PPD in subjects with a proven contact allergy to PPD, who may be allergic to ME-PPD. Hypothesis: In this study subjects will be…

Peanut protein detection in serum and exercise

De objective of this study is to analyse the effect of exercise on the levels of Ara h6 in the blood after peanut consumption. Next to this we would like to know whether these levels found are in associated with the measure of intestinal…

Characterization and localization of microstructural changes in brain tissue in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…

The effect of Alphabodies® against human lnterleukin lL23 in the transplant model of psoriasis, in which a psoriatic lesion is induced in non-lesional skin transplanted onto immune-deficient (BNX) mice by injecting super-antigen activated peripheral blood cells intradermally into the transplant.

Are Alphabodies against IL23 effecive in the transplant model of psoriasis

The effect of Spherical Nucleic Acids on target gene expression in full thickness biopsies taken from lesional skin of volunteers with psoriasis vulgaris.

The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs) on psoriasis skin biopsy gene expression in vitro.

PET imaging of arthritis by specific macrophage targeting in Rheumatoid Arthritis patients - clinical proof of concept studies

Primary aim: Stepwise feasibility study to investigate whether intravenously administered macrophage tracers [11C]DPA-713, [18F]DPA-714 and/or [18F]PEG-folate accumulate in inflamed joints of rheumatoid arthritis patients using PET(-CT).Secondary…

Hemodynamic response assessed by the *HandScan* in hand and wrist joints of patients with osteoarthritis compared to patients with rheumatoid arthritis

The aim of this exploratory study is to compare the hemodynamic response as determined by the HandScan between patients with OA and RA, and to study these hemodynamic responses in relation to disease specific underlying joint pathology (synovial…

Is there a role for duplex ultrasound in patients with a clinical suspicion of temporal arteritis?

Determining the role of duplex ultrasound in patients with a clinical suspicion for temporal arteritis.Determing the sensitivity, specificity, negative predictive value and positive predictive value of duplex ultrasound in patients with a clinical…

Leukocyte dynamics during immune reconstitution after stem-cell transplantation: in vivo labelling of dividing leukocytes using deuterated water

In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.

Investigating normal variability in brain volumes and cognition in a healthy population.

The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…

Photoacoustic detection and monitoring of synovitis in finger joints with rheumatoid arthritis.

-To determine the feasibility of detection of synovitis by photoacoustic imaging using three discrete wavelengths of pulsed light as an early indicator of the presence of RA.-To correlate the photoacoustic markers that are indicative for…

Sensitivity and specificity of thermography to diagnose active arthritis in hand-joints of patients with arthritis psoriatic or rheumatoid arthritis

To determine the sensitivity and specificity of IRT to detect clinical active arthritis in hand-joints of patients with RA or PsA using clinical examination and ultrasonography as gold standard.

Tight control in the vascular endotype of systemic sclerosis.
Improving outcomes in pulmonary arterial hypertension associated with systemic sclerosis using personalized medicine, a predictive study.

Specific objectives:* To analyse the predictive value of the presence of anti-ETaR, anti-AT1R and a reduction in capillary density, for the development of PAH in patients with SSc, alone and in combination.* To analyse whether anti-ETaR, anti-AT1R…

Immediate blood mediated immune response in immunocompromised recipients to islet infusion in vitro

- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients

Development of a psychological expectancy training - phase 3: pilot feasibility testing

With this pilot feasibility study, the feasibility of and satisfaction with an eHealth and serious gaming training based on psychological expectancy mechanisms are evaluated.

Pilot study: Biomarkers for diagnosis of neutrophil inflammatory/ allergic asthma

The aim of this pilot study is to establish Th1/Th2/Th17 patterns in healthy controls by analysing cytokine concentrations in nasal fluid (nasal wash and cotton wool method), saliva and blood. This will be done in order to give an estimation about…

Multiple Sclerosis Family Study - Study to investigate whether rare gene mutations cause Multiple Sclerosis (MS) in ten Dutch families with multiple MS patients

Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…