26 results
To assess the effectiveness of EMDR in RA patients with persistent pain despite inflammation being under control.
The overall aim of this project is to unravel the role of IFN-I in ILD in the known/classified SADs and in ILD with autoimmune features but without a specific SAD diagnosis (IPAF), with as ultimate goal better treatment. Since 13-40% of ILD patients…
Hand function impairment in systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) study
Primary Objective: Determination of risk factors for hand function impairment in systemic sclerosis (SSc) patients with early disease, very early disease and established hand impairment (contractures) at 2 years follow-upSecondary Objective(s):-…
The primary objective is to characterise and understand the heterogeneity in patients with ME/CFS (i.e. comorbidities, variability in symptoms and disease progression, severity, and cognitive and autonomic impairment). Therefore, the secondary…
The aims of this study are:1. To describe the neuropsychiatric profiles associated with DDX3X syndrome, SETD1A syndrome, Koolen-De Vries syndrome, KBG syndrome, DYRK1A syndrome, Jansen-De Vries syndrome, Gabriele-De Vries syndrome, and Smith-Magenis…
to characterize the endometrial immune environment in patients with SLE
Primary Objective:Identify trends in the incidence of skin contact allergy with particular reference to fragrance materials that have not hitherto beentested on a systematic basis.Secondary Objective(s):A subsidiary objective is to gather data on…
Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…
1. Identify biomarkers and risk factors that associate with fibrosis progression or predict transformation into a rapid progressive (fibrosing) phenotype and acute exacerbations in IPF and FPF patients.2. Identify biomarkers and risk factors that…
The main objective of the study is to establish epigenetic patterns of predictor 5*-C-phosphate-G-3* (CpGs) in peripheral blood that are associated with (non-)response to 3 commonly used biologics to treat RA and PsO. Methylation profiles will be…
Objective: 1. To investigate whether T1D individuals with preserved β-cell function exhibit a distinct gut microbial and circulating immune cell signature, leading to a reduced incidence of diabetes complications (CVD, nephropathy, neuropathy, and…
Primary Objective:1. Turnover rate of antigen-specific cells (group I)2. Turnover rate of functional T-cell subsets (group II)Secondary Objective(s):• Determining absolute numbers of antigen (poliovirus, measles, Hepatitis A and Hepatitis B)…
The aim of this study is to characterize the immune system and its changes over time. We aim to identify the factors that influence the kinetics of immune system aging, to describe potential aging endotypes in different individuals, and correlate…
The primary objective of this study is:- to measure the effect of the VR program Reducept on the NRS pain score in patients with inflammatory arthritis with chronic pain despite low disease activity.The secondary objectives are:- to measure the…
Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…
The primary goal of this study is to compare serial paired POC and venous INR measuremtents and to distill an individual conversion factor per patient, enabling the ungoing use of POC-INR measurement also in this patient group.
In this study we aim to answer the question whether TCR diversity becomes limiting at older age and thereby leads to impaired responses to novel antigens. While many studies have suggested a contraction in TCR diversity with age, a one-to-one…
The aim of this study is to evaluate the AUC, disease status, presence of ADAbs and treatment burden when switching from IV to SC IFX maintenance treatment in a real-world cohort of IBD patients on IFX monotherapy and combination therapy.
To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…
We aim to define the growth trajectory of clonal hematopoësis after allogeneic transplantation, and identify potential modulating factors.