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Effects of Single Dose of Bilastine 20mg on Flying Ability in Healthy Volunteers Under Conditions of Simulated Cabin Pressure

Objective: The response over time on daytime alertness and performance will be assessed following a single oral dose of bilastine 20 mg in healthy volunteers performing flying ability tests in a hypobaric chamber with an ambient pressure of 75.2 kPa…

Selective Gamba Food Allergy

The aim of the study is to identify patients with selective gamba-allergy and sensitization patterns for the various allergens in gamba extracts. Comparing sensitization patterns between patients who clinically react to Gamba with patients having a…

Cross-sectional study on determinants of contact dermatitis on the hands of construction workers: etiologic studies and development of a diagnostic tool

Primary objective is to determine the actual occurrence of and risk factors for OCD on the hands of Dutch construction workers.With these new insights into the risk factors for OCD, we aim to develop 1) a new diagnostic tool to be used by…

Comparison of human milk extracellular vesicles in allergic and non-allergic mothers

To define differences in the molecular composition of human milk extracellular vesicles between allergic and non-allergic mothers. Additionally, other differences in human milk composition will be analyzed (cellularity, nutrient content,…

Efficacy and tolerability of Citrus/Cydonia comp.® solution for injection in patients with grass pollen seasonal allergic rhinitis:
Randomised, double-blind, placebo-controlled comparative clinical trial with three parallel treatment groups

1. Clinically relevant reduction of symptom severity by use of Citrus/Cydonia comp. subcutaneous injections 2. To examine the use of rescue medication in the three groups, 3.safety of treatment

A Single Dose Study of the Efficacy, Safety, Tolerability, and Pharmacokinetics of REGN1908-1909 in Allergic Rhinitis Patients Challenged Intranasally with Allergen Extract

Primary objective: to assess the inhibition of allergic responses of a single dose of subcutaneously (SC) administered REGN1908-1909 as measured by total nasal symptom score (TNSS), visual analog scale (VAS) nasal symptoms score, and peak nasal…

Clinical follow up of EuroPrevall birt cohorts
A part of Integrated approaches to Food Allergen and Allergy Risk Management consortium study

To trace new onset of food allergy and clinical evolution of already established food allergy, determining frequencies and patterns of tolerance development. Influence of environmental and behaverioural factors will be investigated.

Evaluation of Pharmacokinetics, Relative Bioavailability, and Safety of PA-101 in Healthy Subjects, Patients with Systemic Mastocytosis, and Patients with Allergic Asthma

To evaluate the plasma pharmacokinetic properties and safety of the research medication in healthy volunteers and in Patients with Systemic Mastocytosis and Allergic Asthma.

Integrity of the Mucosa: effect of Amino acid formula on Gastrointestinal tract epithelium
in adult Eosinophilic esophagitis patients

Primary: To demonstrate that a liquid Neocate product (elemental nutrition) study decreased esophageal eosinophil count to less than 15 eosinophils per high-power field in adult patients with eosinophilic esophagitis.Secondary: To study the effect…

Prospective evaluation of allergen-component resolved diagnostic allergy testing and its relation to clinical features of allergic disease in children

by improving the understanding of the relationship of CRD to clinical expressions of allergic disease in children, this study aims at generating data that can improve the development of tools that will help the primary or secondary care practitioner…

A Double-Blind, Randomised, Placebo-Controlled, Multi-Centre Field Study to
Assess the Efficacy and Safety of HDM-SPIRE in Subjects with a History of House
Dust Mite-Induced Rhinoconjunctivitis

To evaluate the efficacy of HDM-SPIRE in the reduction of symptoms and the use of allergy rescue medication associated with HDM allergy in subjects with clinically relevant symptoms.

Eosinophil Half-life in the Lungs of Asthma patients

The primary objective of this study is to determine the eosinophil lifespans under inflammatory conditions in the blood and lungs of patients with eosinophilic asthma

Non-invasive testing to aid in the diagnosis of allergies using fingermark depositions

The goal of this study is developing a non-invasive method to test for a specfic allergy using fingermarks.