184 results
Primary Objective: Difference in gene expression profiles in peripheral blood cells between reactors and non-reactors on a sting challenge with corresponding functional annotation and a naïve Bayes prediction model for patients at risk of a re-…
zie protocol
by improving the understanding of the relationship of CRD to clinical expressions of allergic disease in children, this study aims at generating data that can improve the development of tools that will help the primary or secondary care practitioner…
Primary:* To investigate associations between genomic variation and occurrence of eosinophilic esophagitis. Secondary:* To systematically collect DNA samples and biopsy specimens for future genetic analysis.* We aim to collect clinical data on all…
The primary objective of this study is to assess the negative predictive value of a Skin Prick Test protocol in subjects with clinical CMA and/or RA.
The aim is to investigate whether a melting tablet that contains birch pollen allergen will decrease the hay fever symptoms and may alleviate the need for conventional allergy symptom-suppressing medication. The purpose of this specific study is…
Primary study objectiveTo investigate the prevalence of asthma in children up to 7 years of age with atopic dermatitis in infancy who received either Nutrilon Pepti with synbiotics or Nutrilon Pepti without synbiotics during 12 weeks in their first…
The study consists of three parts:a) Determine which specific components of a food allergen are important for (the severity of) the reaction.b) Developing a model to predict the severity of a food allergy using specific components (obtained from…
To investigate the therapeutic effect of a selected probiotic mixture on the severity of AD in infants aged 0-15 months. The probiotic mixture has been studied in vitro and has proven IL-10 stimulating effects. Therefore it is thought to decrease AD…
The major research objective is to prove that the consumption of plant stanol ester enriched yogurts can improve immune function in vivo in asthma patients
The objective of this study is to test our hypothesis:Hypothesis - We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive *fingerprint* based on the combination of:…
To understand the development of immunological tolerance for allergens in young children.
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
The present study will investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of ARA 290 administered intravenously to healthy subjects, and of intravenously and subcutaneously administered ARA 290 to renally impaired subjects.
To examine the influence of genetic predisposition, genetic factors, infections and lifestyle of mother and child in relation to 1) allergic diseases and childhood astma;2) childhood overweight and obesity; 3) cardiopulmonary fitness and…
To determine the frequency and suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis and psoriasis patients compared to healthy control subjects (the latter data will be obtained by co-workers at the Brigham and…
1. Randomised controlled determination of the influence of foods on the behaviour of a heterogeneous not-selected group primary school children, during the first two months of the trial. 2. Determination of an IgG or IgE-mediated respons to foods,…
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
Primary Objective: 1) We want to investigate whether carriers of FLG-null mutations show higher responses to exposure to the skin irritant SLS than non-carriers.2) Furthermore, we want to investigate whether carriers of mutations in the genes coding…
Primary objective: Is there a gene expression profile which may predict the long term effect of venom immunotherapy?Secondary objective: Which genes are differentially expressed after venom immunotherapy?