46 results
In this study the dose reponse of compound MT204 on the development of psoriasis in the humanized mouse model is investigated. The efficacy of MT204 is compared to two registered drugs, namely Ustekinumab and Daclizumab.
To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
This study concerns a research that is aimed to investigate the prevalence of the metabolic syndrome in a group of patients known with ANCA-associated vaculitis. Hereby we will compare the presence of the metabolic syndrome between an ANCA-…
Test efficacy of compounds D+E in humanized mouse model of psoriasis.
Is topical application of compound Z effective in reducing the development of psoriasis, induced in this humanized mouse model?
objective
To collect and store a serum sample of each patient that is referred to the Leiden University Medical Centre for evaluation of neuropsychiatric symptoms in SLE.
The primary purpose is validation of the dutch version of a brief health-related quality of life (HRQOL) tool in children with systemic lupus erythematosus (SLE). This tool is called *Simple Measure of Impact of Lupus Erythematosus in Youngsters© (…
Our aims are to identify the clusters of impairments in cognition, behavior, quality of life, and fatigue in children after anti-NMDAR encephalitis, to identify risk factors affecting functional outcome and to assess the progression or remission…
The specific aim of the project is to determine the efficacy of Spherical Nucleic Acids (SNAs), delivered in a gel, on psoriasis skin biopsy gene expression in vitro.
Therefore, the primary objective of the present study is to investigate whether the hyper/hypoventilation or the strength ventilation technique accounts for the observed increase in plasma adrenaline levels. Furthermore, we want to determine whether…
To objectively investigate retinal function deterioration due to the inflammatory process by ERG. To investigate if risk factors for loss of ERG activity in uveitis herald more aggressive immunomodulation treatment to prevent visual loss.
The primary study objective is to examine functionality and usability of a newly developed eHealth and serious gaming intervention, to ensure that the intervention is user-friendly and fits the needs of potential users. Based on these functionality…
To collect demographic, clinical, therapeutic, microbiotic and imaging data in patients with JIA, to build a repository, to find novel biomarkers and to construct computerized models to predict the prognosis in children with JIA af the time of…
The main objective of the study is to see if the test compounds can prevent the development of a psoriatic lesion induced in non-lesional skin from psoriasis patients which has been transplanted onto immune-deficient mice.
The main objective of this study is to characterize the pathogenic B cells and the auto-antibodies that are responsible for causing the myasthenic or pemphigus syndromes. The secondary objective is to generate recombinant antibodies based on the…
Primary Objective:Our primary objective is to generate in-depth immune profiles, which include phenotypic and functional analyses, as well as epigenetic and transcriptomic analyses, of several B cell, T cell, and monocyte subsets, which relate to…
Primary Objectives: To unravel the immunological characteristics of postoperative recurrent CD and study the immunological changes in the IL-23 pathway following treatment with biological agents.Secondary Objectives:To study clinical, endoscopic and…
To compare the microbiome, histology, immunohistochemistry and gene expression profile of healthy skin from the axillae or groin of 10 healthy volunteers with uninvolved axilla or groin skin from age, gender, body mass index, and smoking status…
The main aim of the proposed study is to 1) assess the habitual consumption of raw cow*s milk among a large population of adult dairy farmers; 2) assess the association between raw cow*s milk consumption and inflammation-related, auto-immune and…