28 results
Primary objective;Confirm superiority of IgG antibody levels against pertussis toxin (Ptx), present in the acellular vaccines, in infants at the age of 3 months of mothers having received a pertussis vaccine during pregnancy versus infants of…
The aim of this study is to determine whether Staphylococcus aureus colonizes the human throat and the perineal area independent of the nose.
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
The aim of this study is to compare the colonization capacity of methicillin-susceptible S. aureus (MSSA) from animal and human origin in a human nose inoculation experiment.
To assess the effect of alternative and reduced doses pneumococcal vaccination schedules using the 13-valent pneumococcal conjugate vaccine (PCV13, Wyeth) on the development of antibody titers directed against the different serotypes of pneumococci…
Primary: To determine trends in nasopharyngeal colonization with total vaccine- and non-vaccine serotypes of S. pneumoniae in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch National Immunization Program…
Primary: To compare immunogenicity (humoral and cellular) induced by PCV10 and PCV13 after the booster dose of a complete vaccination series (3+1, the current NIP schedule) Secondary: To compare immunogenicity (humoral) induced by PCV10 and PCV13 at…
1) To determine the prevalence and the sensitivity for various antibiotics of Staphylococcus aureus in the nose (carrier) of patients visiting the outpatient department of Dermatology.2) To determine the prevalence and the sensitivity for various…
Primary goal:Determination of the number of MRSA-carriers among persons in the direct surroundings of a person (index) with an infection by MRSA.Secundary goal:1. To determine if and how MRSA-colonisation spontaneously (dis)appears or spreads among…
see protocol
The primary objective of this study is to determine the prevalence of V-MRSA in areas with high density of pig farming compared to the expected prevalence of MRSA in the general population of The Netherlands and as a secondary objective to assess…
zie J. aanvullende opmerkingen
Our study will measure several different symptoms/aspects of cellulitis, such as redness, swelling, warmth, pain, fluctuation, ulceration and drainage. Each of these aspects will be scored on a scale of 0-3, adding up to a maximum total score of 21…
a pilot study will be performed to gain understanding in cognitive functioning in patients with chronic Q-fever or QFS compared to matched controls.
Primary• To determine changes over time, since introduction of PCV vaccination in National Immunization Program, in nasopharyngeal colonization frequencies of total vaccine- and non-vaccine serotypes of S. pneumoniae in healthy 24-month-old and 46-…
the first objective of this study is to quantify the impact of chronic Q-fever or QFS on work status and psychosocial functioning. Secondly, we will identify factors that are associated with these limitations, to determine which subgroups of…
Investigate the effects of aP booster vaccination in children, young adults and elderly on the (long-term) immune response to B. pertussis in three European countries with a different epidemiological background and primary vaccination schedule for…
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*
Our primary objective is to evaluate non-inferiority of anti-Pertussis Toxin (PT) IgG in term infants at 2m of age born of mothers having received a pertussis vaccine between 20-24w Gestational Age (GA) compared to a reference anti-PT IgG at 2m of…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
We aim to determine the impact and seriousness of other TBDs in the Netherlands by measuring the prevalence and describing the clinical picture and the course of different other TBDs.