100 results
Primary objective;Confirm superiority of IgG antibody levels against pertussis toxin (Ptx), present in the acellular vaccines, in infants at the age of 3 months of mothers having received a pertussis vaccine during pregnancy versus infants of…
To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.
To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…
The purpose of this trial is to evaluate whether procalcitonin measurements are able to reduce antibiotic usage in Dutch intensive care units by reducing the duration of antibiotic treatment.
The aim of this study is to determine whether Staphylococcus aureus colonizes the human throat and the perineal area independent of the nose.
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…
First, to explore relationships between immunological factors (cytokines and chemokines), psychological stress, and pain, controlled for infection. Second, to explore relationships between immunological factors (MBL), bacterial colonisation and…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
The primary objective of the study is to determine sensitivity, specificity, positive and negative predictive value of the enzyme analyses (myeloperoxidase, human neutrophil elastase and lysozyme) with wound biopsies as the gold standard.…
(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and
The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…
The aim of this study is to compare the colonization capacity of methicillin-susceptible S. aureus (MSSA) from animal and human origin in a human nose inoculation experiment.
Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…
To assess the effect of alternative and reduced doses pneumococcal vaccination schedules using the 13-valent pneumococcal conjugate vaccine (PCV13, Wyeth) on the development of antibody titers directed against the different serotypes of pneumococci…
To explore the association between MBL level at baseline and the incidence of febrile neutropenia.
The purpose of this study is to obtain an impression of the general image quality and clinical value of leucocyte PET/CT in visualizing infectious foci in the body.
To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.