95 results
To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
In this study we will for the first time combine in-vitro stimulation assays and high throughput sequencing to identify, quantify and phenotype the clones that play a functional role in influenza infections and follow them over time. This will lead…
a. To assess the burden of mumps in the student population.b. To describe the risk factors for mumps virus infection (symptomatic and asymptomatic). c. To determine the relative contribution of household transmission and transmission at the party to…
To determine the expression of inhibitory receptors on immune competent cells in patients and healthy controls
Evaluate the prevalence, consistency, and genotype distribution of human papillomavirus (HPV) in semen and to examine the exact localization of HPV (i.e., in the seminal fluid and/or on the membrane or cytoplasm of the sperm cell).Evaluate the…
The aim of this study is to determine the risk factors in infants for obtaining a severe HPeV infection. For this purpose, we will test the hypothesis that (maternal) HPeV specific antibodies are protective against (severe) HPeV infections in young…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
Our hypothesis is: HBV interferes with the function of intrahepatic innate immune cells, especially NK cells. Since NK cells play a major role in anti-viral immunity and NK cells comprise a large proportion of the intrahepatic immune cells, we would…
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
2.1 Primary Objective• Evaluation of the levels of thrombophilic factors in the blood of HIV-infected patients before starting with cART and the changes of these levels when on cART for the time of one year. 2.2 Secondary Objective• Evaluation of…
* To study HIV-1 sequence dynamics and HIV-1 evolution in donor-recipient pairs in relation to host and viral factors.* To detect and characterize the differences in transmitted virus in donor-recipient pairs as soon as possible after transmission.
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The objective of this research is to identify genetic host factors influencing the clinical course and treatment of HIV infection. The identification of these genes may lead to new therapeutic or preventive approaches. In addition, the…
To examine the transmission of HIV variants.Have 1 or more viruses been transmitted?To examine the course of HIV-infection. Are differences in the course of HIV infection with same type viruses caused by genetic hostfactors Course more unfavourable…
Determine associations between genetic variation and immune response in nasopharyngeal aspirates of infants with RSV LRTI.
The hypothesis of this study is that children that are vaccinated since birth will have significant less or no cross protective CTLs compared to children that have not been vaccinated since birth. Objective: Determination of the effect of annual…
Primary aimTo evaluate the effects of peginterferon and ribavirin therapy on the immune response in chronic HCV genotype 1 patients before, during and after treatment.Secondary aims1. To determine if differential modulation of Treg activity or DC…
By using white blood cells of mono- and dizygotic twins (compare results) we would like to determine which part of the observed dispersion can be explained by genetic host factors.