95 results
- To compare the course and determinants of the SARS-CoV-2-specific humoral and cellular immune response in AID patients upon primary SARS-CoV-2 infection to that in healthy controls (HC)- To determine the seroconversion rate, magnitude and…
The primary objective (1) of the proposed study is to isolate and characterize neutralizing monoclonal antibodies from patients who recovered from COVID-19 infection. The secondary objective (2) is to isolate and characterize monoclonal antibodies…
Identifying the pro-inflammatory biomarker profile in the pathophysiology of acute sever lung disease in SARS-CoV-2 infection, and using this profile to identify the patients who are at risk of developing acute severe lung disease and multi-organ…
To evaluate the prevalence of SARS-CoV2 antibodies in breast milk of lactating mothers recovering from a proven or suspected SARS-CoV2 infection.Secundary: to evaluate the effect of the corona-pandemic on pyschological en biological stress in…
Research objective: Transcriptome data from main immune cell types (monocytes, CD4+ and CD8+ T cells, B-cells, NK cells) of post-COVID patients are analyzed using STP technology. STP-activity results are interpreted in combination with clinical…
To quantify the strength and direction of interactions between important respiratory virus infections in young children
To study the antibody response as a disease modifying factor in the context of COVID-19, we will compare the anti-CoV antibody composition, quality and interaction with immune receptors.
Primary Objectives: 1. To investigate the nature and extent of persistent fatigue and cognitive complaints 2. To investigate the impact of persistent complaints on health-related quality of life and health care consumption3. To identify risk factors…
To validate biomarkers that are associated with severe RSV infection and respiratory sequelae.
Primary objective: To obtain a detailed immunological profile of children presenting to Dutch hospitals with acute SARS-CoV-2 infection or with a SARS-CoV-2 related post-infectious inflammatory syndrome. Secondary objectives: (1) To correlate the…
The primary objective of the NOVA study is the establishment of a prospective cohort study of patients that initiate cART during the acute infection phase. The secondary objective is to characterize the viro-immunological factors that correlate with…
This study is a follow-up study of the NOVICE I & NOVICE II (METC 2012_093 and METC 2016_173). The objective of the study is to both cross-sectionally and longitudinally, after an interval of 10 years, gain more insight into the presence,…
The SILVER study aims to give insight into the half-life of maternally acquired antibodies in preterms and the foetus to mother transfer function. These findings have implications for understanding infectious disease susceptibility, vaccine…
The aim of this study is to improve our understanding of clinical, virological, and psychosocial outcomes in patients with MPXVID. To get a better understanding of associated risk factors for MPXV infection, and to measure quality of life and stigma…
The primary objective is to study protective antibody responses after SARS-CoV-2 vaccination in patients with pSS. Secondary objectives are monitoring of adverse events and disease activity after vaccination, studying the prognostic value of anti-…
Primary objective: To investigate the prevalence of SARS-CoV-2 presence in the cerebrospinal fluid (CSF) of patients with a proven SARS-CoV-2 infection and acute respiratory failure.Secondary objectives: 1. To correlate the presence of SARS-CoV-2 in…
a) To determine the occurrence of subclinical and clinical disease and transmission of SARS-CoV-2 in families with children aged 14-18 years; and b) to examine the associations of socio-demographic and lifestyle, genetic, and epigenetic factors with…
The aim of this study is to collect nasal fluid (mucosal lining fluid) from patients with a confirmed SARS-CoV-2 infection who remain in home isolation, as well as from their household contacts who remain in home quarantine. We aim to measure…
To characterize the presence of anti-Covid-19 IgM and anti-Covid-19 IgG in volunteering employees of the Department of Gastroenterology and Hepatology of the Erasmus MC.
Primary objective: Dissection of the cellular and serological immune response against SARS-CoV2 with special attention for SARS-CoV2 specific T-cell & B-cell responses and antibody formation against viral proteins as well as for innate…