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Multimodal treatment of perianal fistulas in Crohn's disease: seton vs anti-TNF vs advancement plasty

Currently, there is no guideline for the treatment of perianal Crohn's fistulas. the aim of this study, in which surgical strategies (seton drainage and surgical closure with advancement plasty/LIFT) will be compared to medical treatment. We…

Prevention of septic complications in low anterior resection for rectal carcinoma: the role of Platelet Derived Growth Factors. A pilot study

To investigate the feasibility of using L-PRP on anastomosis to prevent septic complications from occuring.

A prospective single-blinded randomized multi-center clinical trial comparing the clinical efficacy and patient acceptability of open selective haemorrhoidopexy with stapled haemorrhoidopexy

The purpose of this prospective randomised trial is 1) to compare short- and long-term efficacy of open selective haemorrhoidopexy with stapled haemorrhoidopexy; 2) to compare patients satisfaction between open and stapled haemorrhoidopexy.

Anorectal function and the effect of childbirth in patients with M Crohn

Disease activity, perianal involvement and lesion localisation are important influential parameters making sure no pregnancy is exactly alike and mode of delivery needs to be considered on an individual patient level.A complete anorectal function…

Pelvic floor therapy in the treatment of all anal fissures; a multicentre, randomized controlled trial

To assess the potential benefit of pelvic floor therapy for anal fissure. Measured primarily in pain, measured by the VAS score. Secondary outcomes are healing rates and recurrence.

Longterm outcome of biological mesh closure of the pelvic floor after extralevator abdominoperineal resection for rectal cancer.

The aim of this study is to determine the cost-effectiveness of pelvic floor reconstruction using a biological mesh afterstandardized eAPR with neo-adjuvant (chemo)radiotherapy.