232 results
Primary Objective: We want to estimate cut off values for clinically appropriate hypoperfusion of the pharyngeal mucosa and the skin in the neck. Secondary Objective: We want to compare perfusion rate of PTL to perfusion rate in STL in order to…
This study has been transitioned to CTIS with ID 2023-506604-18-00 check the CTIS register for the current data. Primary:- To evaluate the safety and tolerability of SGN-PDL1V in subjects with advanced solid tumors.- To identify the maximum…
This study has been transitioned to CTIS with ID 2024-513843-10-00 check the CTIS register for the current data. Primary objective: Assess the short term safety and tolerability of 68Ga-SATO in pediatric patients with NBLSecondary objectives: -…
This study has been transitioned to CTIS with ID 2023-509707-32-00 check the CTIS register for the current data. To investigate whether the response rate of pembrolizumab exceeds the response rate of the historic control in locally advanced,…
The primary objective in this trial is to evaluate the use of MRI and contrast enhanced mammography after using MagTrace® to perform a breast conserving surgery and a sentinel node biopsy.
Primary Objective: To assess the safety profile (AEs, SAEs) on combined treatment with tamoxifen and testosterone.Secondary Objectives:• AR to ER ratio on baseline FES- and FDHT-PET imaging (assessed per lesion and per patient by quantitative…
To detect differences between ACC patients and controls without ACC, and between the diseased and healthy adrenal gland of ACC patients, in microRNA (miRNA), circulating cell-free tumor DNA (ctDNA), circulating tumor cells (CTCs), and steroid…
Objectives: The immunogenic effects of adrenal SMART schemes may vary even though the local tumor control rates are high. Our objective is to study the dose-related immunological signals accompanying the delivery of SMART to adrenal metastases using…
This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…
The primary outcome parameters are identification rate of SLN(s) or lymph node metastases with bevacizumab-800CW, defined as the number of patients in which a SLN or lymph node metastasis was detected due to fluorescence during surgery and/or…
Primary Objective: To test the feasibility of online neuropsychological assessments using the Amsterdam Cognition Scan (ACS) compared to classical neuropsychological assessments in patients with cancers with CNS involvement.
Primary objective:Part 1: To determine the safety, tolerability, and RP2D of a daily dosing schedule (induction) of GSK3745417 Part 2: To evaluate clinical efficacy following the daily dosing *induction* period of GSK3745417 in participants with…
This study has been transitioned to CTIS with ID 2023-505313-24-00 check the CTIS register for the current data. To evaluate the treatment effect of CAM2029 compared to placebo on liver volume in patients with polycystic liver disease (PLD)
Primary objective of this open label, two-arm, multicenter, multinational, randomized trial is to compare anit-leukemic activity of allogeneic stem cell transplantation for patients with acute leukemia in complete remission between a 10/10 HLA…
To assess the impact of SABR, compared to standard of care treatment, on overall survival, oncologic outcomes, and quality of life in patients with a controlled primary tumor and 4-10 metastatic lesions.
The primary objective of this study is to examine whether MIS is non-inferior to laparotomy in terms of disease free survival (DFS) in women with advanced stage EOC that received 3 to 4 cycles of NACT.
Primary objective:• To investigate the efficacy, defined as clinical benefit (stable disease (SD), partial response (PR), complete response (CR)) at 12 weeks, confirmed on a second scan after 4 weeks, of an FMT-intervention with responder and non-…
The aim is to evaluate whether the use of eRFA prior to stenting prolongs stent patency in patients with biliary obstruction due to inoperable perihilar cholangocarcinoma.
Clinical safety study on 5-Aminolevulinic acid (5-ALA) in children and adolescents with brain tumors
This study has been transitioned to CTIS with ID 2024-517575-20-00 check the CTIS register for the current data. This study proposes a safety study in children in which tumors are operated on using fluorescence-guided resection which are similar to…
The aim of this study is to determine the feasibility of perioperative (continuous) remote patient monitoring using Ehealth devices and a daily questionnaire in patients undergoing major gastrointestinal surgery. Additionally, to determine (early)…