227 results
The main aim of this study is to assess the prevalence of allergic and non-allergic health problems in veterinary students in different phases of the veterinary education. On later stage, genetic predisposition for allergies will be studied. In the…
The main aim of this follow-up study is to assess the incidence of respiratory disorders, like allergy, asthma and asthma like-syndrome, in association with the interaction of environmental and genetic risk factors in veterinary students. In order…
* Establish the relationship between plasma levels and the development of infectious complications. * Determine the genetic variants of the MBL-gene.
To study the spread of STI among heterosexual males and females (heterosexuals) in Amsterdam in order to provide information for building evidence-based prevention strategies and to evaluate existing control programs. Three substudies are part of…
To determine the efficacy of the combination of everolimus and capecitabine in a group of patients with metastatic or locally advanced HCC with Child-Pugh class B liver cirrhosis. In addition, to investigate biomarkers of HCC before and during the…
To determine incidence, aetiology and course of gastroenteritis in case of hospitalisation with gastroenteritis. To gain insight in pathogen-specific duration, seriousness of the disease (including complications), and mortality. To investigate…
The primary objective of the present study is to assess the agreement rate of Scintimun® Granulocyte and 99mTc-WBCs with regard to the diagnosis of infection/inflammation by immunoscintigraphy, based on the evaluations of three blinded and…
1. To study the possible association between MBL-deficiency and the occurence and severity of infections in MBL-deficient CF patients.2. To study the possible association between MBL-deficiency and the severity of cystic fibrosis.3. To study the…
To identify predictive factors for response to sunintib treatment in patients with HCC. By discovering changes in pathways involved in HCC carcinogenesis due to sunitinib treatment in tissue/biomarkers and to correlate these changes to FDG-PET scan…
Goal of this study is to obtain more insight into causative agents of respiratory tract infections in children using molecular techniques and how results of molecular test should be interpretated in relation to clinical symptoms. The optimal…
Primary objective: - to test the hypothesis that an initial negative PET scan can be change in 4 months in a positive PET scan.Secondary objective:- to test the hypothesis that a negative PET scan is related to a less aggressive tumor with an…
PROPOSAL PART I - TYMPANOSTOMY TUBE INSERTION Objective: Regarding children suffering from Acute or Chronic Otitis Media:Are there biological markers present in blood (and middle ear fluid), which will inform us about:1. The risk of recurrent…
The objective of this study is to identify direct or indirect pruritogens accumulating during cholestasis and to analyze the involved neuronal signaling pathways leading to the sensation of itch.
To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…
Validation of MRI with Primovist® for differentiation of FNH and HCA.Do imaging and histological outcome correlate?Is it possible to use MRI with Primovist® (as gold standard) in the diagnostic work-up of FNH and HCA?
Improve the insight in the aetiology of CAP by season and by population in the Netherlands by the use of an extensive combination of microbiological techniques.Moreover this study will provide an unique sample from a well defined patient population…
The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…
The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…
To identify new blood based protein biomarkers for the diagnosis of sepsis.
The aim of the study is to evaluate whether the HBV serological response to Infanrix hexa vaccination, after administration according to the Dutch National Immunisation Programme, is sufficient according to World Health Organisation (WHO) standrads…