47 results
To identify pathogenic bacterial biofilms in UC-patients with and without neoplasia in tandem with host factors such as barrier defects and carcinogenic pathway activation in a prospective cohort study.
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
Primary Objective(s): 1. To obtain preliminary data on whether (and to which extend) adjuvant chemotherapy for colon cancer results in (a) deterioration of contractile muscle properties and increased muscle fatigability, (b) increased inflammation…
We have developed the TES program, which involves Targeted selection and Enhanced care, delivered on the basis of Stepped care (TES). The primary study aim is to evaluate the effectiveness of the TES-program compared to usual care in reducing…
Brown adipose tissue activity and energy metabolism in cachexia induced by cancer or chronic disease
To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.
The primary aim is to study colon motility following rectal resection with the construction of a deviating ileostomy in patients that received an enema as bowel preparation. We hypothesise that CTT is halted or decreased, similar as in patients that…
This study examines the effect of systematic geriatic screening, via a geriatric oncology care module and geriatric interventions, on the quality of life of patients aged 70 years or older with colorectal carcinoma. We also examine whether…
To unravel the genetic makeup of colorectal cancer (CRC) in adolescents and young adults (AYAs) in order to improve genetic counseling, surveillance and, ultimately, treatment and disease outcome.
To directly evaluate the gastric tube microcirculation with Dark Sidestream imaging during minimal invasive esophageal resection on several locations, i.e. from best arterial blood supply (antrum) to worst (fundus). Furthermore, to evaluate the…
The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…
Primary objective: Adherence in patients starting the use of capecitabine and the influence of patients attitudes and side effects on adherence.Secondary objective: The second part of this study contains 1) a validation study of the adherence…
This study will contribute to improving quality of care for cancer survivors, since sexual problems seem to be profound but not always discussed with patients. Patients are now often insufficiently informed and do not know how to interpret their…
The purpose of this study is to investigate the role of adipokines-secretion in visceral adipose tissue and its influence on the risk for esophageal adenocarcinoma. Examination of adipose tissue may provide important insight into mechanistic links…
The primary objective is to generate genome-wide miRNA profiles of patient material (tissue samples and blood). The secondary objectives are to compare miRNA expression profiles to investigate what role differences in miRNA expression have in the…
Primary objective of this study is the identification of familial germline mutations in SPS. Secondary objectives are to get a better insight in the molecular pathway of SPS and associated colorectal carcinoma, to discriminate those family members…
To determine the composition of immune cells and the expression of immunological factors in normal squamous esophagus, RE, BE and EAC.
1.What are ulcerative colitis patients* understanding of their risk of colon cancer and the benefit of colonoscopy?2. What is ulcerative colitis patients* threshold of cancer risk before accepting colectomy in the setting of dysplasia?3. What are…
The primary objective of this study is to evaluate the prevalence and risk of advanced colorectal neoplasia in asymptomatic non-PSC post-liver transplant recipients compared to an age- and sex matched general population.Secondary Objectives- To…
To find procoagulant markers predictive of progression of the underlying malignancy or predictive of the occurrence of a venous thrombotic event.
The present study aims to investigate genetic factors that contribute to the development of BE.