18 results
1) To prove that it is possible to safely reduce the number of invasive cystoscopies during follow-up (FUP) of patients with NMIBC with a low/intermediate risk of recurrence or progression. 2) To prove that addition of urine tests to the follow-up…
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
The aim of this research is developing a non-invasive a method of early detection of CIS using scrotal ultrasound and semen diagnostic on CIS-cells. The results of this research will be used for the set-up of a screening study of CIS at men with an…
Can we identify a gene expression profile for late radiation toxicity?
Primary Objectives: a. Optimization of the 99MTc-HABN SPECT/CT scanning protocol in the first 5 patients (Phase 0). b. Detection and characterization of primary prostate cancer (tumor uptake and tumor-to-background ratio) in patients with 99MTc-HABN…
To apply a novel blood assay to 150 patients undergoing a radical prostatectomy in order to assess whether this test can accurately identify indolent cancers and thereby prevent unnecessary treatments. To increase the accuracy of the flow cytometric…
The primary objective is to compare the sensitivity and specificity of tumour size and growth assessed with HistoScanningTM with the PRIAS parameters (PSA changes). The sensitivity and specificity of both methods will be measured with adverse biopsy…
To investigate the difference between side and end-firing in transrectal prostate needle biopsies in terms of qualitative and quantitative prostate cancer detection.
The following objectives have been defined for PROCABIO:1. Integration of biomarkers in an updated and improved model for the prediction of indolent prostate cancer.2. Integration of biomarkers in the development of guidelines for efficient…
To investigate if contrast enhanced ultrasound can improve prostate brachytherapy outcomes. Besides that we will investigate if contrast enhanced ultrasound can be used as an extra verification of follow up after treatment.
Determine the following:1) What is thé main harbouring site of HPV in men ?2) What is the golden standard for male HPV screening ?3) What is the main HPV genotype in men ?4) Is there a HPV genotype specific anotomical site in men?
Primary Objective: * To evaluate the ability to concentrate the radiotracer within the prostate gland improving the evaluation of the primary prostate tumor. Secondary Objective(s): * To evaluate the PET/CT imaging characteristics of transcatheter,…
To study the value of mpMRI with subsequent targeted biopsies after inclusion to more accurately grade prostate cancers of men on active surveillance. Furthermore, the value of mpMRI in reducing the number and amount of biopsies will be studied.
The primary objectives of the Radium223Insight study are: 1. To identify biomarkers for early identification of clinical benefit from radium-223 treatment in mCRPC patients. 2. To better understand immune response during radium-223 treatment in…
Improvement of late radiation toxicity prediction comes with three practical advantages for patients with a tumor in the pelvic area:(1) patients with a high risk of developing late radiation toxicity may not need to be treated with radiation, but…
Primary Objective: The primary outcome of this study is successful implementation of home-based blood sampling. The success criteria is that 25% or more of the blood assessments are actually performed at home by the patients themselves using a self-…
Primary objective: 1. To establish whether obtaining CTCs of mHSPC patients by DLA for single cell genotyping and phenotyping warrants further clinical exploration. Secondary objectives: 1. To investigate the number of CTCs in peripheral blood of…
The main objective is to determine whether testing for TSLC1 methylation in hrHPV positive women with abnormal cytology better predicts underlying high-grade cervical lesions necessitating ablative treatment.