152 results
To study the value of molecular biomarkers in cytology samples (cervical scrape, vaginal sample and urine) for cancer detection in patients with gynaecologic cancer.
3.1 Primary Objective• Feasibility of Magtrace® as a tracer in SLN sampling in early stage EOC.3.2 Secondary Objectives• Comparison of detection rate between MagTrace® and 99mTco In the general cohorto In primary staging laparotomyo In secondary…
Primary objectives: To optimize ex vivo testing procedures for cervical cancer patients derived tumor tissue tumoroids culturing from tissue from the primary tumor.To evaluate the success rate of ex vivo drug sensitivity testing for cervical cancer…
This study has been transitioned to CTIS with ID 2023-503267-42-00 check the CTIS register for the current data. Primary:• 3 year recurrence free survival (RFS), in patients with MMRd HREC Secondary:• RFS (median and at 5 years)• OS (median, 3yr,…
The primary objective is to gain more insight in molecular alterations in CSU by performing a broad set of molecular analysis on tissue and blood ofpatients with carcinosarcoma of the uterus and find (bio)markers which can be linked to the clinical…
We expect the BMI and the type of fat distribution to have a significant influence on the change in hormone levels, fat metabolism and systemic inflammation levels after bilateral salpingo-oophorectomy (BSO). In patients with endometrial cancer,…
Primary objective:- To determine the difference in mean dose (Gy) to pelvic bones (whole pelvic contour), and the difference in the mean V15Gy-bowelbag volume in cc (according to EMBRACE bowel bag definition) between photon and proton therapy in…
The primary objective of this study is to assess the feasibility of EM-navigation for gynaecological brachytherapy catheter placement.
This study has been transitioned to CTIS with ID 2023-508722-99-00 check the CTIS register for the current data. Primary objective:- Investigate the safety of replacing inguinofemoral lymphadenectomy by chemoradiation in early stage vulvar cancer…
This study has been transitioned to CTIS with ID 2024-516736-10-00 check the CTIS register for the current data. Based on the success of the pilot feasibility study, we propose a follow-up efficacy study to explore neo-adjuvant ICB therapy as…
Primary Objectives: Determine oncologic outcomes after fertility-sparing treatment in AYAs with cervical, ovarian or endometrial cancer (Q1). Determine fertility and obstetric outcomes after fertility-sparing treatment in AYAs with cervical, ovarian…
The primary objective of the study is to estimate the clinical benefit of cemiplimab + ISA101b after progression on first line chemotherapy, as assessed by objective response rate (ORR).The secondary objectives of the study are:• To characterize the…
This study has been transitioned to CTIS with ID 2024-516327-14-00 check the CTIS register for the current data. This study is evaluating the preliminary efficacy of UV1-olaparib-durvalumab combination against both olaparib as monotherapy and…
This study aims to evaluate the potential of growing out TIL from several patients with cervical carcinoma.
This study has been transitioned to CTIS with ID 2023-506361-56-00 check the CTIS register for the current data. This study is designed to assess the efficacy and safety of pembrolizumab monotherapy compared with SoC platinum doublet chemotherapy…
1. What is the level of psychological distress among cervical cancer patients over time?2. What is the role of characteristics of the individual, characteristics of the environment, biological function, overall quality of life, functional status and…
To determine the diagnostic performance and potential clinical benefit of DW-MRI as a staging tool to identify patients with advanced stage ovarian cancer who can benefit from cytoreductive surgery.
Primary: To determine whether the outcome of the RAD51 assay (HR proficient or HR deficient) correlates with objective response rate (RR) of olaparib, in patients with recurrent high grade epithelial ovarian cancer.Secondary:• Compare the…
To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…