185 results
This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…
Clinical safety study on 5-Aminolevulinic acid (5-ALA) in children and adolescents with brain tumors
This study has been transitioned to CTIS with ID 2024-517575-20-00 check the CTIS register for the current data. This study proposes a safety study in children in which tumors are operated on using fluorescence-guided resection which are similar to…
Implement BBB-ASL at VUmc and assess the reliability and reproducibility of f measurements in healthy volunteers and patients with glioma
The primary objective is to examine relationships between neurocognitive performance and MRI parameters of brain vasculature, metabolism, and white matter diffusion in children who have been treated for posterior fossa tumor. Secondary objectives…
Primary objectives:To demonstrate that diagnostic sensitivity of plasma metanephrines (free and total) is superior to standard evaluation procedures (urinary Dopamine, HVA and VMA) at diagnosis and end-of-induction assessment.Secondary objectives:•…
Generate proof-of-concept of using a physiological CTV for radiotherapy treatment planning for patients with brain tumours.
The primary objective is to determine the effect of high-dose sunitinib versus standard treatment with lomustine on six-month progression-free survival (PFS6) in patients with recurrent GBM, using the RANO criteria. Secondary objectives are:1. To…
The main goal is to identify risk factors for radiation induced cognitive changes. Therefore, cerebral hemodynamic status of the patient, measured as cerebrovascular reactivity (CVR) with magnetic resonance imaging (MRI), at the start of radiation…
This study is performed to investigate the optimal strategy for maintaining quality of life and improving survival in elderly patients (65 years or older) diagnosed with primary GBM. Primary endpoints of the study are: 1) Proportion of patients with…
1) To collect information on patient characteristics, short and long-term clinical and patient reported outcomes and those of his/her caregiver. 2) To evaluate feasibility, performance and added value of new magnetic resonance imaging (MRI)…
In this study we will investigate whether there is a difference in PSMA expression between BM and RN by:1. Evaluating PSMA expression using Ga68-PSMA PET/CT in BM of NSCLC, melanoma and breastcancer patients eligible for SRT or surgery.2. Evaluating…
Firstly, to assess the ability of fUS to discriminate between functional and non-functional spinal cord areas using electrical stimulation paradigms during spinal cord tumor removal surgery. Secondly, to assess the ability of fUS to discriminate…
This study has been transitioned to CTIS with ID 2022-502668-20-00 check the CTIS register for the current data. PHASE 1 OBJECTIVES:Primary:To determine the safety of oral larotrectinib , including dose-limiting toxicity (DLT), in pediatric patients…
This study has been transitioned to CTIS with ID 2024-512222-28-00 check the CTIS register for the current data. Overall program:The overall aim of this project is to improve the outcome of patients diagnosed with ependymoma by improving the staging…
This study has been transitioned to CTIS with ID 2024-513724-42-00 check the CTIS register for the current data. PNET 5 MB-LR: Primary objective:-to confirm that the 3-year Event-Free Survival (EFS) rate in children and adolescents with standard-…
Primary objective: To assess NCF, HRQoL, mood, fatigue, cognitive complaints and health care utilization in long-term surviving patients with anaplastic oligondendroglioma and oligoastrocytoma.Secondary objective:To assess cerebral abnormalities in…
This study has been transitioned to CTIS with ID 2023-507933-12-00 check the CTIS register for the current data. MAIN OBJECTIVES:- To compare the efficacy of Dato-DXd in combination with pembrolizumab versus pembrolizumab alone, as measured by…
Primary objective:• To demonstrate that the probability for reduced coverage of the recurrence volume by a radiotherapy plan based on a CTVbio, compared to the clinical radiotherapy plan (1.5-cm CTV), is lower than 0.20.Secondary objectives: • To…
The primary objective is to develop and clinically validate a fast multi-parametric MRI acquisition technique, for non-invasive and comprehensive characterization of the tumor*s vascularization, *vascular signature mapping*, at 3 Tesla (3T) and 7…
[Retrospective clinical path:1) main objective: to identify predictors (sociodemographic, clinical, imaging, and (neuro)psychological variables) of objective cognitive functioning of all patients who undergo neurosurgyer, at 3 months after surgery2…