296 results
Primary objective of the study:- The primary objective for this study is to determine the prognostic characteristics for BPAR in the first 3 months after transplantation, as assessed in the lymphocyte composition of the lymph node in immunologically…
The primary objective is to assess whether RDN by other devices than Medtronic added to usual care compared to usual care alone reduces BP in subjects, classified as non-responders on renal denervation, six months after RDN.
Based on this background information and our preliminary data in this project we aim to perform longitudinal study in cystinosis patients to correlate clinical course under cysteamine therapy and 1) Markers of macrophage activation in patients…
The objective of this study is to achieve better adherence to fluid restriction by providing insight to patient*s drinking behavior, by using the MySleeve device (MS).
To investigate whether a 200 mg bid fixed dosage regimen of ciprofloxacin achieves concentrations associated with maximal efficacy and minimal spread of resistance in ICU patients undergoing CVVHD.
To study the effect of renal clearance on the biological variation and the circadian rhythm of cardiac troponin.
This study assesses the effect of oral iron supplementation on gut-derived plasma uremic toxin levels in patients with chronic kidney disease (CKD) and with iron deficiency. The main research questions to be answered are:1. Does oral iron…
With this study we will investigate the effects of lumbar sympathetic blockade on ERPF and measured GFR and relative changes in non - invasive hemodynamics measured before and after continuous lumbar sympathetic blockade or splanchnic blockade in…
To assess the degree of arterial wall inflammation as measured by 18F-FDG-PET/CT in subjects with chronic kidney disease.
In the current study, we intend to study the diagnostic accuracy of promising urine biomarkers for early detection of acute kidney injury in patients undergoing major general surgery. The study is designed to validate earlier findings in a large…
To perform a detailed non-invasive analysis of mechanical activation under different volume loading conditions and to describe the accompanying hemodynamic response.
Investigate whether restoration of intestinal butyratelevels improves the intestinal barrier function and decreases the inflammatory status in CKD patients.
Objective: To test the efficacy and safety of percutaneous renal sympathetic denervation of the native kidneys in the treatment of uncontrolled hypertension in kidney transplant recipients.
To make MRI suitable for an MRI-only workflow for magnetic resonance (MR)-guided (MR-linac) stereotactic radiotherapy for localized RCC. The objective of the current study will be MRI-sequence optimisation. Sequences will be optimized for MR-based…
The effect of deep muscle relaxation on the abdominal working space during laparosopy, measured by MRI.
Primary:* Evaluate the long-term safety of multiple doses of ALN-GO1 in patients with PH1.Secundary:* Evaluate the pharmacodynamic (PD) effect of ALN-GO1 on urinary oxalate excretion* Characterize the effect of ALN-GO1 on markers of renal function.…
To assess the efficacy and safety of vaccination against COVID-19 in patients with CKD4/5, patients on dialysis, and kidney transplant recipients as compared to controls
The aim of the follow-up study is to determine the differences between early versus late treatment with GZ / SAR402671 in the effect on total kidney volume growth (total kidney volume, TKV) and in the effect on slowing down renal impairment (change…
The purpose of this study is to investigate how quickly and to which extent the new study compound BI 690517 is absorbed, transported,and eliminated from the body. BI 690517 is an investigational study compound which has not yet been approved for…
The main objective is to investigate whether the variant indeed cause mitochondrial dysfunction leading to the observed phenotype, including characterization of the pathophysiology.